Targeted removal of mitochondrial DNA from mouse and human extrachromosomal circular DNA with CRISPR-Cas9

Extrachromosomal circular DNA (eccDNA) of chromosomal origin is common in eukaryotic cells. Amplification of oncogenes on large eccDNA (ecDNA) can drive biological processes such as tumorigenesis, and identification of eccDNA by sequencing after removal of chromosomal DNA is therefore important for...

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Detalles Bibliográficos
Autores principales: Feng, Weijia, Arrey, Gerard, Zole, Egija, lv, Wei, Liang, Xue, Han, Peng, Mohiyuddin, Marghoob, Pilegaard, Henriette, Regenberg, Birgitte
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Research Network of Computational and Structural Biotechnology 2022
Materias:
Method Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9233219/
https://www.ncbi.nlm.nih.gov/pubmed/35782732
http://dx.doi.org/10.1016/j.csbj.2022.06.028

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