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Sema3A Antibody BI-X Prevents Cell Permeability and Cytoskeletal Collapse in HRMECs and Increases Tip Cell Density in Mouse Oxygen-Induced Retinopathy

PURPOSE: Semaphorin 3A (Sema3A) is an axonal guidance molecule that inhibits angiogenesis by vasorepulsion and blocks revascularization in the ischemic retina. BI-X is an intravitreal anti-Sema3A agent under clinical investigation in patients with proliferative diabetic retinopathy (PDR) and diabeti...

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Detalles Bibliográficos
Autores principales:	Zippel, Nina, Kenny, Cynthia Hess, Wu, Helen, Garneau, Michel, Kroe-Barrett, Rachel, Gupta, Priyanka, Low, Sarah, Bakker, Remko A., Thomas, Leo
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	The Association for Research in Vision and Ophthalmology 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9233289/ https://www.ncbi.nlm.nih.gov/pubmed/35727188 http://dx.doi.org/10.1167/tvst.11.6.17

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