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Comorbidities and COVID-19 status influence the survival rate of geriatric patients in intensive care units: a prospective cohort study from the Indonesian Society of Anaesthesiology and Intensive Therapy
BACKGROUND: With the more advanced science in the field of medicine and disease management, the population of geriatric intensive care patients is increasing. The COVID-19 pandemic has impacted healthcare management around the globe, especially on critically-ill elderly patients. We aim to analyse t...
Autores principales: | , , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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BioMed Central
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9233386/ https://www.ncbi.nlm.nih.gov/pubmed/35752756 http://dx.doi.org/10.1186/s12877-022-03227-9 |
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author | Rehatta, Nancy Margarita Chandra, Susilo Sari, Djayanti Lestari, Mayang Indah Senapathi, Tjokorda Gde Agung Nurdin, Haizah Wirabuana, Belindo Pramodana, Bintang Pradhana, Adinda Putra Isngadi, Isngadi Anggraeni, Novita Sikumbang, Kenanga Marwan Halimi, Radian Ahmad Jasa, Zafrullah Khany Nasution, Akhyar Hamonangan Mochamat, Mochamat Purwoko, Purwoko |
author_facet | Rehatta, Nancy Margarita Chandra, Susilo Sari, Djayanti Lestari, Mayang Indah Senapathi, Tjokorda Gde Agung Nurdin, Haizah Wirabuana, Belindo Pramodana, Bintang Pradhana, Adinda Putra Isngadi, Isngadi Anggraeni, Novita Sikumbang, Kenanga Marwan Halimi, Radian Ahmad Jasa, Zafrullah Khany Nasution, Akhyar Hamonangan Mochamat, Mochamat Purwoko, Purwoko |
author_sort | Rehatta, Nancy Margarita |
collection | PubMed |
description | BACKGROUND: With the more advanced science in the field of medicine and disease management, the population of geriatric intensive care patients is increasing. The COVID-19 pandemic has impacted healthcare management around the globe, especially on critically-ill elderly patients. We aim to analyse the relationship between underlying illnesses, including COVID-19, and the survival rate of elderly patients who are treated in the intensive care setting. METHODS: We conducted a prospective cohort study at 14 teaching hospitals for Anaesthesiology and Intensive Therapy Education in Indonesia. We selected all subjects with 60 years of age or older in the period between February to May 2021. Variables recorded included subject characteristics, comorbidities, and COVID-19 status. Subjects were followed for 30-day mortality as an outcome. We analysed the data using Kaplan-Meier survival analysis. RESULTS: We recruited 982 elderly patients, and 728 subjects were in the final analysis (60.7% male; 68.0 ± 6.6 years old). The 30-day mortality was 38.6%. The top five comorbidities are hypertension (21.1%), diabetes (16.2%), moderate or severe renal disease (10.6%), congestive heart failure (9.2%), and cerebrovascular disease (9.1%). Subjects with Charlson’s Comorbidity Index Score > 5 experienced 66% death. Subjects with COVID-19 who died were 57.4%. Subjects with comorbidities and COVID-19 had lower survival time than subjects without those conditions (p < 0.005). Based on linear correlation analysis, the more comorbidities the geriatric patients in the ICU had, the higher chance of mortality in 30 days (p < 0.005, R coefficient 0.22). CONCLUSION: Approximately one in four elderly intensive care patients die, and the number is increasing with comorbidities and COVID-19 status. |
format | Online Article Text |
id | pubmed-9233386 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-92333862022-06-26 Comorbidities and COVID-19 status influence the survival rate of geriatric patients in intensive care units: a prospective cohort study from the Indonesian Society of Anaesthesiology and Intensive Therapy Rehatta, Nancy Margarita Chandra, Susilo Sari, Djayanti Lestari, Mayang Indah Senapathi, Tjokorda Gde Agung Nurdin, Haizah Wirabuana, Belindo Pramodana, Bintang Pradhana, Adinda Putra Isngadi, Isngadi Anggraeni, Novita Sikumbang, Kenanga Marwan Halimi, Radian Ahmad Jasa, Zafrullah Khany Nasution, Akhyar Hamonangan Mochamat, Mochamat Purwoko, Purwoko BMC Geriatr Research BACKGROUND: With the more advanced science in the field of medicine and disease management, the population of geriatric intensive care patients is increasing. The COVID-19 pandemic has impacted healthcare management around the globe, especially on critically-ill elderly patients. We aim to analyse the relationship between underlying illnesses, including COVID-19, and the survival rate of elderly patients who are treated in the intensive care setting. METHODS: We conducted a prospective cohort study at 14 teaching hospitals for Anaesthesiology and Intensive Therapy Education in Indonesia. We selected all subjects with 60 years of age or older in the period between February to May 2021. Variables recorded included subject characteristics, comorbidities, and COVID-19 status. Subjects were followed for 30-day mortality as an outcome. We analysed the data using Kaplan-Meier survival analysis. RESULTS: We recruited 982 elderly patients, and 728 subjects were in the final analysis (60.7% male; 68.0 ± 6.6 years old). The 30-day mortality was 38.6%. The top five comorbidities are hypertension (21.1%), diabetes (16.2%), moderate or severe renal disease (10.6%), congestive heart failure (9.2%), and cerebrovascular disease (9.1%). Subjects with Charlson’s Comorbidity Index Score > 5 experienced 66% death. Subjects with COVID-19 who died were 57.4%. Subjects with comorbidities and COVID-19 had lower survival time than subjects without those conditions (p < 0.005). Based on linear correlation analysis, the more comorbidities the geriatric patients in the ICU had, the higher chance of mortality in 30 days (p < 0.005, R coefficient 0.22). CONCLUSION: Approximately one in four elderly intensive care patients die, and the number is increasing with comorbidities and COVID-19 status. BioMed Central 2022-06-25 /pmc/articles/PMC9233386/ /pubmed/35752756 http://dx.doi.org/10.1186/s12877-022-03227-9 Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data. |
spellingShingle | Research Rehatta, Nancy Margarita Chandra, Susilo Sari, Djayanti Lestari, Mayang Indah Senapathi, Tjokorda Gde Agung Nurdin, Haizah Wirabuana, Belindo Pramodana, Bintang Pradhana, Adinda Putra Isngadi, Isngadi Anggraeni, Novita Sikumbang, Kenanga Marwan Halimi, Radian Ahmad Jasa, Zafrullah Khany Nasution, Akhyar Hamonangan Mochamat, Mochamat Purwoko, Purwoko Comorbidities and COVID-19 status influence the survival rate of geriatric patients in intensive care units: a prospective cohort study from the Indonesian Society of Anaesthesiology and Intensive Therapy |
title | Comorbidities and COVID-19 status influence the survival rate of geriatric patients in intensive care units: a prospective cohort study from the Indonesian Society of Anaesthesiology and Intensive Therapy |
title_full | Comorbidities and COVID-19 status influence the survival rate of geriatric patients in intensive care units: a prospective cohort study from the Indonesian Society of Anaesthesiology and Intensive Therapy |
title_fullStr | Comorbidities and COVID-19 status influence the survival rate of geriatric patients in intensive care units: a prospective cohort study from the Indonesian Society of Anaesthesiology and Intensive Therapy |
title_full_unstemmed | Comorbidities and COVID-19 status influence the survival rate of geriatric patients in intensive care units: a prospective cohort study from the Indonesian Society of Anaesthesiology and Intensive Therapy |
title_short | Comorbidities and COVID-19 status influence the survival rate of geriatric patients in intensive care units: a prospective cohort study from the Indonesian Society of Anaesthesiology and Intensive Therapy |
title_sort | comorbidities and covid-19 status influence the survival rate of geriatric patients in intensive care units: a prospective cohort study from the indonesian society of anaesthesiology and intensive therapy |
topic | Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9233386/ https://www.ncbi.nlm.nih.gov/pubmed/35752756 http://dx.doi.org/10.1186/s12877-022-03227-9 |
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