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Abdominal obesity phenotypes are associated with the risk of developing non-alcoholic fatty liver disease: insights from the general population
BACKGROUND: The diversity of obesity-related metabolic characteristics generates different obesity phenotypes and corresponding metabolic diseases. This study aims to explore the correlation of different abdominal obesity phenotypes with non-alcoholic fatty liver disease (NAFLD). METHODS: The curren...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9233393/ https://www.ncbi.nlm.nih.gov/pubmed/35752753 http://dx.doi.org/10.1186/s12876-022-02393-9 |
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author | Kuang, Maobin Lu, Song Xie, Qiyang Peng, Nan He, Shiming Yu, Changhui Qiu, Jiajun Sheng, Guotai Zou, Yang |
author_facet | Kuang, Maobin Lu, Song Xie, Qiyang Peng, Nan He, Shiming Yu, Changhui Qiu, Jiajun Sheng, Guotai Zou, Yang |
author_sort | Kuang, Maobin |
collection | PubMed |
description | BACKGROUND: The diversity of obesity-related metabolic characteristics generates different obesity phenotypes and corresponding metabolic diseases. This study aims to explore the correlation of different abdominal obesity phenotypes with non-alcoholic fatty liver disease (NAFLD). METHODS: The current study included 14,251 subjects, 7411 males and 6840 females. Abdominal obesity was defined as waist circumference ≥ 85 cm in males and ≥ 80 cm in females; according to the diagnostic criteria for metabolic syndrome recommended by the National Cholesterol Education Program Adult Treatment Panel III, having more than one metabolic abnormality (except waist circumference criteria) was defined as metabolically unhealthy. All subjects were divided into 4 abdominal obesity phenotypes based on the presence ( +) or absence (− ) of metabolically healthy/unhealthy (MH) and abdominal obesity (AO) at baseline: metabolically healthy + non-abdominal obesity (MH(−)AO(−)); metabolically healthy + abdominal obesity (MH(−)AO(+)); metabolically unhealthy + non-abdominal obesity (MH(+)AO(−)); metabolically unhealthy + abdominal obesity (MH(+)AO(+)). The relationship between each phenotype and NAFLD was analyzed using multivariate logistic regression. RESULTS: A total of 2507 (17.59%) subjects in this study were diagnosed with NAFLD. The prevalence rates of NAFLD in female subjects with MH(−)AO(−), MH(−)AO(+), MH(+)AO(−), and MH(+)AO(+) phenotypes were 1.73%, 24.42%, 7.60%, and 59.35%, respectively. Among male subjects with MH(−)AO(−), MH(−)AO(+), MH(+)AO(−), and MH(+)AO(+) phenotypes, the prevalence rates were 9.93%, 50.54%, 25.49%, and 73.22%, respectively. After fully adjusting for confounding factors, with the MH(−)AO(−) phenotype as the reference phenotype, male MH(−)AO(+) and MH(+)AO(+) phenotypes increased the risk of NAFLD by 42% and 47%, respectively (MH(−)AO(+): OR 1.42, 95%CI 1.13,1.78; MH(+)AO(+): OR 1.47, 95%CI 1.08,2.01); the corresponding risks of MH(−)AO(+) and MH(+)AO(+) in females increased by 113% and 134%, respectively (MH(−)AO(+): OR 2.13, 95%CI 1.47,3.09; MH(+)AO(+): OR 2.34, 95%CI 1.32,4.17); by contrast, there was no significant increase in the risk of NAFLD in the MH(+)AO(−) phenotype in both sexes. CONCLUSIONS: This first report on the relationship of abdominal obesity phenotypes with NAFLD showed that both MH(−)AO(+) and MH(+)AO(+) phenotypes were associated with a higher risk of NAFLD, especially in the female population. These data provided a new reference for the screening and prevention of NAFLD. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s12876-022-02393-9. |
format | Online Article Text |
id | pubmed-9233393 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-92333932022-06-26 Abdominal obesity phenotypes are associated with the risk of developing non-alcoholic fatty liver disease: insights from the general population Kuang, Maobin Lu, Song Xie, Qiyang Peng, Nan He, Shiming Yu, Changhui Qiu, Jiajun Sheng, Guotai Zou, Yang BMC Gastroenterol Research BACKGROUND: The diversity of obesity-related metabolic characteristics generates different obesity phenotypes and corresponding metabolic diseases. This study aims to explore the correlation of different abdominal obesity phenotypes with non-alcoholic fatty liver disease (NAFLD). METHODS: The current study included 14,251 subjects, 7411 males and 6840 females. Abdominal obesity was defined as waist circumference ≥ 85 cm in males and ≥ 80 cm in females; according to the diagnostic criteria for metabolic syndrome recommended by the National Cholesterol Education Program Adult Treatment Panel III, having more than one metabolic abnormality (except waist circumference criteria) was defined as metabolically unhealthy. All subjects were divided into 4 abdominal obesity phenotypes based on the presence ( +) or absence (− ) of metabolically healthy/unhealthy (MH) and abdominal obesity (AO) at baseline: metabolically healthy + non-abdominal obesity (MH(−)AO(−)); metabolically healthy + abdominal obesity (MH(−)AO(+)); metabolically unhealthy + non-abdominal obesity (MH(+)AO(−)); metabolically unhealthy + abdominal obesity (MH(+)AO(+)). The relationship between each phenotype and NAFLD was analyzed using multivariate logistic regression. RESULTS: A total of 2507 (17.59%) subjects in this study were diagnosed with NAFLD. The prevalence rates of NAFLD in female subjects with MH(−)AO(−), MH(−)AO(+), MH(+)AO(−), and MH(+)AO(+) phenotypes were 1.73%, 24.42%, 7.60%, and 59.35%, respectively. Among male subjects with MH(−)AO(−), MH(−)AO(+), MH(+)AO(−), and MH(+)AO(+) phenotypes, the prevalence rates were 9.93%, 50.54%, 25.49%, and 73.22%, respectively. After fully adjusting for confounding factors, with the MH(−)AO(−) phenotype as the reference phenotype, male MH(−)AO(+) and MH(+)AO(+) phenotypes increased the risk of NAFLD by 42% and 47%, respectively (MH(−)AO(+): OR 1.42, 95%CI 1.13,1.78; MH(+)AO(+): OR 1.47, 95%CI 1.08,2.01); the corresponding risks of MH(−)AO(+) and MH(+)AO(+) in females increased by 113% and 134%, respectively (MH(−)AO(+): OR 2.13, 95%CI 1.47,3.09; MH(+)AO(+): OR 2.34, 95%CI 1.32,4.17); by contrast, there was no significant increase in the risk of NAFLD in the MH(+)AO(−) phenotype in both sexes. CONCLUSIONS: This first report on the relationship of abdominal obesity phenotypes with NAFLD showed that both MH(−)AO(+) and MH(+)AO(+) phenotypes were associated with a higher risk of NAFLD, especially in the female population. These data provided a new reference for the screening and prevention of NAFLD. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s12876-022-02393-9. BioMed Central 2022-06-25 /pmc/articles/PMC9233393/ /pubmed/35752753 http://dx.doi.org/10.1186/s12876-022-02393-9 Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data. |
spellingShingle | Research Kuang, Maobin Lu, Song Xie, Qiyang Peng, Nan He, Shiming Yu, Changhui Qiu, Jiajun Sheng, Guotai Zou, Yang Abdominal obesity phenotypes are associated with the risk of developing non-alcoholic fatty liver disease: insights from the general population |
title | Abdominal obesity phenotypes are associated with the risk of developing non-alcoholic fatty liver disease: insights from the general population |
title_full | Abdominal obesity phenotypes are associated with the risk of developing non-alcoholic fatty liver disease: insights from the general population |
title_fullStr | Abdominal obesity phenotypes are associated with the risk of developing non-alcoholic fatty liver disease: insights from the general population |
title_full_unstemmed | Abdominal obesity phenotypes are associated with the risk of developing non-alcoholic fatty liver disease: insights from the general population |
title_short | Abdominal obesity phenotypes are associated with the risk of developing non-alcoholic fatty liver disease: insights from the general population |
title_sort | abdominal obesity phenotypes are associated with the risk of developing non-alcoholic fatty liver disease: insights from the general population |
topic | Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9233393/ https://www.ncbi.nlm.nih.gov/pubmed/35752753 http://dx.doi.org/10.1186/s12876-022-02393-9 |
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