Electroporation-Mediated Delivery of Cas9 Ribonucleoproteins Results in High Levels of Gene Editing in Primary Hepatocytes

Adeno-associated virus vectors are the most used delivery method for liver-directed gene editing. Still, they are associated with significant disadvantages that can compromise the safety and efficacy of therapies. Here, we investigate the effects of electroporating CRISPR-Cas9 as mRNA and ribonucleo...

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Detalles Bibliográficos
Autores principales: Rathbone, Tanner, Ates, Ilayda, Fernando, Lawrence, Addlestone, Ethan, Lee, Ciaran M., Richards, Vincent P., Cottle, Renee N.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Mary Ann Liebert, Inc., publishers 2022
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9233506/
https://www.ncbi.nlm.nih.gov/pubmed/35238624
http://dx.doi.org/10.1089/crispr.2021.0134

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