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Efficient and Fast Generation of Relevant Disease Mouse Models by In Vitro and In Vivo Gene Editing of Zygotes

Knockout mice for human disease-causing genes provide valuable models in which new therapeutic approaches can be tested. Electroporation of genome editing tools into zygotes, in vitro or within oviducts, allows for the generation of targeted mutations in a shorter time. We have generated mouse model...

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Detalles Bibliográficos
Autores principales:	Sanchez-Baltasar, Raquel, Garcia-Torralba, Aida, Nieto-Romero, Virginia, Page, Angustias, Molinos-Vicente, Andrea, López-Manzaneda, Sergio, Ojeda-Pérez, Isabel, Ramirez, Angel, Navarro, Manuel, Segovia, José Carlos, García-Bravo, María
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Mary Ann Liebert, Inc., publishers 2022
Materias:	Research Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9233508/ https://www.ncbi.nlm.nih.gov/pubmed/35686982 http://dx.doi.org/10.1089/crispr.2022.0013

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