The Origins and Functions of De Novo Genes: Against All Odds?

“De novo” genes evolve from previously non-genic DNA. This strikes many of us as remarkable, because it seems extraordinarily unlikely that random sequence would produce a functional gene. How is this possible? In this two-part review, I first summarize what is known about the origins and molecular...

Descripción completa

Detalles Bibliográficos
Autor principal: Weisman, Caroline M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer US 2022
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9233646/
https://www.ncbi.nlm.nih.gov/pubmed/35451603
http://dx.doi.org/10.1007/s00239-022-10055-3
_version_ 1784735827695239168
author Weisman, Caroline M.
author_facet Weisman, Caroline M.
author_sort Weisman, Caroline M.
collection PubMed
description “De novo” genes evolve from previously non-genic DNA. This strikes many of us as remarkable, because it seems extraordinarily unlikely that random sequence would produce a functional gene. How is this possible? In this two-part review, I first summarize what is known about the origins and molecular functions of the small number of de novo genes for which such information is available. I then speculate on what these examples may tell us about how de novo genes manage to emerge despite what seem like enormous opposing odds.
format Online
Article
Text
id pubmed-9233646
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher Springer US
record_format MEDLINE/PubMed
spelling pubmed-92336462022-06-27 The Origins and Functions of De Novo Genes: Against All Odds? Weisman, Caroline M. J Mol Evol Review “De novo” genes evolve from previously non-genic DNA. This strikes many of us as remarkable, because it seems extraordinarily unlikely that random sequence would produce a functional gene. How is this possible? In this two-part review, I first summarize what is known about the origins and molecular functions of the small number of de novo genes for which such information is available. I then speculate on what these examples may tell us about how de novo genes manage to emerge despite what seem like enormous opposing odds. Springer US 2022-04-22 2022 /pmc/articles/PMC9233646/ /pubmed/35451603 http://dx.doi.org/10.1007/s00239-022-10055-3 Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Review
Weisman, Caroline M.
The Origins and Functions of De Novo Genes: Against All Odds?
title The Origins and Functions of De Novo Genes: Against All Odds?
title_full The Origins and Functions of De Novo Genes: Against All Odds?
title_fullStr The Origins and Functions of De Novo Genes: Against All Odds?
title_full_unstemmed The Origins and Functions of De Novo Genes: Against All Odds?
title_short The Origins and Functions of De Novo Genes: Against All Odds?
title_sort origins and functions of de novo genes: against all odds?
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9233646/
https://www.ncbi.nlm.nih.gov/pubmed/35451603
http://dx.doi.org/10.1007/s00239-022-10055-3
work_keys_str_mv AT weismancarolinem theoriginsandfunctionsofdenovogenesagainstallodds
AT weismancarolinem originsandfunctionsofdenovogenesagainstallodds

Ejemplares similares