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The role of cholesterol binding in the control of cholesterol by the Scap–Insig system
Scap and Insig, two proteins embedded in the membrane of the endoplasmic reticulum (ER), regulate the synthesis of cholesterol in animal cells by forming a dimer in the presence of high concentrations of cholesterol. Cryo-electron microscopic structures for the Scap–Insig dimer show a sterol-binding...
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Springer International Publishing
2022
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9233655/ https://www.ncbi.nlm.nih.gov/pubmed/35717507 http://dx.doi.org/10.1007/s00249-022-01606-z |