Titanium wear from magnetically controlled growing rods (MCGRs) for the treatment of spinal deformities in children

Magnetically controlled growing rods (MCGRs) are an effective treatment method for early-onset scoliosis (EOS). In recent years, increasing titanium wear was observed in tissue adjacent to implants and in blood samples of these patients. This study aims to investigate the potential correlation betwe...

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Autores principales: Lüders, K. A., Braunschweig, L., Zioła-Frankowska, A., Stojek, A., Jakkielska, D., Wichmann, A., Dihazi, G. H., Streit, F., Güsewell, S. E., Trüe, T. C., Lüders, S., Schlie, J., Tsaknakis, K., Lorenz, H. M., Frankowski, M., Hell, A. K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9233686/
https://www.ncbi.nlm.nih.gov/pubmed/35752736
http://dx.doi.org/10.1038/s41598-022-15057-1
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author Lüders, K. A.
Braunschweig, L.
Zioła-Frankowska, A.
Stojek, A.
Jakkielska, D.
Wichmann, A.
Dihazi, G. H.
Streit, F.
Güsewell, S. E.
Trüe, T. C.
Lüders, S.
Schlie, J.
Tsaknakis, K.
Lorenz, H. M.
Frankowski, M.
Hell, A. K.
author_facet Lüders, K. A.
Braunschweig, L.
Zioła-Frankowska, A.
Stojek, A.
Jakkielska, D.
Wichmann, A.
Dihazi, G. H.
Streit, F.
Güsewell, S. E.
Trüe, T. C.
Lüders, S.
Schlie, J.
Tsaknakis, K.
Lorenz, H. M.
Frankowski, M.
Hell, A. K.
author_sort Lüders, K. A.
collection PubMed
description Magnetically controlled growing rods (MCGRs) are an effective treatment method for early-onset scoliosis (EOS). In recent years, increasing titanium wear was observed in tissue adjacent to implants and in blood samples of these patients. This study aims to investigate the potential correlation between amount of metal loss and titanium levels in blood during MCGR treatment as well as influencing factors for metal wear. In total, 44 MCGRs (n = 23 patients) were retrieved after an average of 2.6 years of implantation and analyzed using a tactile measurement instrument and subsequent metal loss calculation. Titanium plasma levels (n = 23) were obtained using inductively coupled plasma-mass spectrometry (ICP-MS). The correlation of both parameters as well as influencing factors were analyzed. Titanium abrasion on MCGRs was observed in the majority of implants. There was no correlation of metal implant wear or titanium plasma values to the duration of MCGR implantation time, number of external lengthening procedures, patient’s ambulatory status, gender, weight or height. Material loss on the MCGRs showed a positive correlation to titanium blood plasma values. The present study is one of the first studies to analyze retrieved MCGRs using high-precision metrological techniques and compare these results with ICP-MS analyses determining blood titanium values.
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spelling pubmed-92336862022-06-27 Titanium wear from magnetically controlled growing rods (MCGRs) for the treatment of spinal deformities in children Lüders, K. A. Braunschweig, L. Zioła-Frankowska, A. Stojek, A. Jakkielska, D. Wichmann, A. Dihazi, G. H. Streit, F. Güsewell, S. E. Trüe, T. C. Lüders, S. Schlie, J. Tsaknakis, K. Lorenz, H. M. Frankowski, M. Hell, A. K. Sci Rep Article Magnetically controlled growing rods (MCGRs) are an effective treatment method for early-onset scoliosis (EOS). In recent years, increasing titanium wear was observed in tissue adjacent to implants and in blood samples of these patients. This study aims to investigate the potential correlation between amount of metal loss and titanium levels in blood during MCGR treatment as well as influencing factors for metal wear. In total, 44 MCGRs (n = 23 patients) were retrieved after an average of 2.6 years of implantation and analyzed using a tactile measurement instrument and subsequent metal loss calculation. Titanium plasma levels (n = 23) were obtained using inductively coupled plasma-mass spectrometry (ICP-MS). The correlation of both parameters as well as influencing factors were analyzed. Titanium abrasion on MCGRs was observed in the majority of implants. There was no correlation of metal implant wear or titanium plasma values to the duration of MCGR implantation time, number of external lengthening procedures, patient’s ambulatory status, gender, weight or height. Material loss on the MCGRs showed a positive correlation to titanium blood plasma values. The present study is one of the first studies to analyze retrieved MCGRs using high-precision metrological techniques and compare these results with ICP-MS analyses determining blood titanium values. Nature Publishing Group UK 2022-06-25 /pmc/articles/PMC9233686/ /pubmed/35752736 http://dx.doi.org/10.1038/s41598-022-15057-1 Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Article
Lüders, K. A.
Braunschweig, L.
Zioła-Frankowska, A.
Stojek, A.
Jakkielska, D.
Wichmann, A.
Dihazi, G. H.
Streit, F.
Güsewell, S. E.
Trüe, T. C.
Lüders, S.
Schlie, J.
Tsaknakis, K.
Lorenz, H. M.
Frankowski, M.
Hell, A. K.
Titanium wear from magnetically controlled growing rods (MCGRs) for the treatment of spinal deformities in children
title Titanium wear from magnetically controlled growing rods (MCGRs) for the treatment of spinal deformities in children
title_full Titanium wear from magnetically controlled growing rods (MCGRs) for the treatment of spinal deformities in children
title_fullStr Titanium wear from magnetically controlled growing rods (MCGRs) for the treatment of spinal deformities in children
title_full_unstemmed Titanium wear from magnetically controlled growing rods (MCGRs) for the treatment of spinal deformities in children
title_short Titanium wear from magnetically controlled growing rods (MCGRs) for the treatment of spinal deformities in children
title_sort titanium wear from magnetically controlled growing rods (mcgrs) for the treatment of spinal deformities in children
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9233686/
https://www.ncbi.nlm.nih.gov/pubmed/35752736
http://dx.doi.org/10.1038/s41598-022-15057-1
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