Occult polyclonality of preclinical pancreatic cancer models drives in vitro evolution

Heterogeneity is a hallmark of cancer. The advent of single-cell technologies has helped uncover heterogeneity in a high-throughput manner in different cancers across varied contexts. Here we apply single-cell sequencing technologies to reveal inherent heterogeneity in assumptively monoclonal pancre...

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Detalles Bibliográficos
Autores principales: Monberg, Maria E., Geiger, Heather, Lee, Jaewon J., Sharma, Roshan, Semaan, Alexander, Bernard, Vincent, Wong, Justin, Wang, Fang, Liang, Shaoheng, Swartzlander, Daniel B., Stephens, Bret M., Katz, Matthew H. G., Chen, Ken, Robine, Nicolas, Guerrero, Paola A., Maitra, Anirban
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9233687/
https://www.ncbi.nlm.nih.gov/pubmed/35752636
http://dx.doi.org/10.1038/s41467-022-31376-3

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