Tumor endothelial cell-derived extracellular vesicles contribute to tumor microenvironment remodeling

Cancer progression involves several biological steps where angiogenesis is a key tumorigenic phenomenon. Extracellular vesicles (EVs) derived from tumor cells and other cells in the tumor microenvironment (TME) help modulate and maintain favorable microenvironments for tumors. Endothelial cells (ECs...

Descripción completa

Detalles Bibliográficos
Autores principales: Gao, Jian, Zhang, Xiaodong, Jiang, Lei, Li, Yan, Zheng, Qianqian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2022
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9233793/
https://www.ncbi.nlm.nih.gov/pubmed/35752798
http://dx.doi.org/10.1186/s12964-022-00904-5
_version_ 1784735882779033600
author Gao, Jian
Zhang, Xiaodong
Jiang, Lei
Li, Yan
Zheng, Qianqian
author_facet Gao, Jian
Zhang, Xiaodong
Jiang, Lei
Li, Yan
Zheng, Qianqian
author_sort Gao, Jian
collection PubMed
description Cancer progression involves several biological steps where angiogenesis is a key tumorigenic phenomenon. Extracellular vesicles (EVs) derived from tumor cells and other cells in the tumor microenvironment (TME) help modulate and maintain favorable microenvironments for tumors. Endothelial cells (ECs) activated by cancer-derived EVs have important roles in tumor angiogenesis. Interestingly, EVs from ECs activate tumor cells, i.e. extracellular matrix (ECM) remodeling and provide more supplements for tumor cells. Thus, EV communications between cancer cells and ECs may be effective therapeutic targets for controlling cancer progression. In this review, we describe the current knowledge on EVs derived from ECs and we examine how these EVs affect TME remodeling. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s12964-022-00904-5.
format Online
Article
Text
id pubmed-9233793
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher BioMed Central
record_format MEDLINE/PubMed
spelling pubmed-92337932022-06-27 Tumor endothelial cell-derived extracellular vesicles contribute to tumor microenvironment remodeling Gao, Jian Zhang, Xiaodong Jiang, Lei Li, Yan Zheng, Qianqian Cell Commun Signal Review Cancer progression involves several biological steps where angiogenesis is a key tumorigenic phenomenon. Extracellular vesicles (EVs) derived from tumor cells and other cells in the tumor microenvironment (TME) help modulate and maintain favorable microenvironments for tumors. Endothelial cells (ECs) activated by cancer-derived EVs have important roles in tumor angiogenesis. Interestingly, EVs from ECs activate tumor cells, i.e. extracellular matrix (ECM) remodeling and provide more supplements for tumor cells. Thus, EV communications between cancer cells and ECs may be effective therapeutic targets for controlling cancer progression. In this review, we describe the current knowledge on EVs derived from ECs and we examine how these EVs affect TME remodeling. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s12964-022-00904-5. BioMed Central 2022-06-25 /pmc/articles/PMC9233793/ /pubmed/35752798 http://dx.doi.org/10.1186/s12964-022-00904-5 Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Review
Gao, Jian
Zhang, Xiaodong
Jiang, Lei
Li, Yan
Zheng, Qianqian
Tumor endothelial cell-derived extracellular vesicles contribute to tumor microenvironment remodeling
title Tumor endothelial cell-derived extracellular vesicles contribute to tumor microenvironment remodeling
title_full Tumor endothelial cell-derived extracellular vesicles contribute to tumor microenvironment remodeling
title_fullStr Tumor endothelial cell-derived extracellular vesicles contribute to tumor microenvironment remodeling
title_full_unstemmed Tumor endothelial cell-derived extracellular vesicles contribute to tumor microenvironment remodeling
title_short Tumor endothelial cell-derived extracellular vesicles contribute to tumor microenvironment remodeling
title_sort tumor endothelial cell-derived extracellular vesicles contribute to tumor microenvironment remodeling
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9233793/
https://www.ncbi.nlm.nih.gov/pubmed/35752798
http://dx.doi.org/10.1186/s12964-022-00904-5
work_keys_str_mv AT gaojian tumorendothelialcellderivedextracellularvesiclescontributetotumormicroenvironmentremodeling
AT zhangxiaodong tumorendothelialcellderivedextracellularvesiclescontributetotumormicroenvironmentremodeling
AT jianglei tumorendothelialcellderivedextracellularvesiclescontributetotumormicroenvironmentremodeling
AT liyan tumorendothelialcellderivedextracellularvesiclescontributetotumormicroenvironmentremodeling
AT zhengqianqian tumorendothelialcellderivedextracellularvesiclescontributetotumormicroenvironmentremodeling

Ejemplares similares