Targeted biallelic integration of an inducible Caspase 9 suicide gene in iPSCs for safer therapies

Drug-inducible suicide systems may help to minimize risks of human induced pluripotent stem cell (hiPSC) therapies. Recent research challenged the usefulness of such systems since rare drug-resistant subclones were observed. We have introduced a drug-inducible Caspase 9 suicide system (iCASP9) into...

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Detalles Bibliográficos
Autores principales: Wunderlich, Stephanie, Haase, Alexandra, Merkert, Sylvia, Jahn, Kirsten, Deest, Maximillian, Frieling, Helge, Glage, Silke, Korte, Wilhelm, Martens, Andreas, Kirschning, Andreas, Zeug, Andre, Ponimaskin, Evgeni, Göhring, Gudrun, Ackermann, Mania, Lachmann, Nico, Moritz, Thomas, Zweigerdt, Robert, Martin, Ulrich
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society of Gene & Cell Therapy 2022
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9234009/
https://www.ncbi.nlm.nih.gov/pubmed/35795779
http://dx.doi.org/10.1016/j.omtm.2022.05.011

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