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Comprehensive analysis of the novel omicron receptor AXL in cancers

The SARS-CoV-2 is constantly mutating, and the new coronavirus such as Omicron has spread to many countries around the world. Anexelekto (AXL) is a transmembrane protein with biological functions such as promoting cell growth, migration, aggregation, metastasis and adhesion, and plays an important r...

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Autores principales: Zhang, Wei-Na, Li, Xue-Ping, Wang, Peng-Fei, Zhu, Lu, Xiao, Xin-Hua, Dai, Yu-Jun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Research Network of Computational and Structural Biotechnology 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9234055/
https://www.ncbi.nlm.nih.gov/pubmed/35782741
http://dx.doi.org/10.1016/j.csbj.2022.06.051
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author Zhang, Wei-Na
Li, Xue-Ping
Wang, Peng-Fei
Zhu, Lu
Xiao, Xin-Hua
Dai, Yu-Jun
author_facet Zhang, Wei-Na
Li, Xue-Ping
Wang, Peng-Fei
Zhu, Lu
Xiao, Xin-Hua
Dai, Yu-Jun
author_sort Zhang, Wei-Na
collection PubMed
description The SARS-CoV-2 is constantly mutating, and the new coronavirus such as Omicron has spread to many countries around the world. Anexelekto (AXL) is a transmembrane protein with biological functions such as promoting cell growth, migration, aggregation, metastasis and adhesion, and plays an important role in cancers and coronavirus disease 2019 (COVID-19). Unlike angiotensin-converting enzyme 2 (ACE2), AXL was highly expressed in respiratory system cells. In this study, we verified the AXL expression in cancer and normal tissues and found AXL expression was strongly correlated with cancer prognosis, tumor mutation burden (TMB), the microsatellite instability (MSI) in most tumor types. Immune infiltration analysis also demonstrated that there was an inextricable link between AXL expression and immune scores in cancer patients, especially in BLCA, BRCA and CESC. The NK-cells, plasmacytoid dendritic cells, myeloid dendritic cells, as one of the important components of the tumor microenvironment, were highly expressed AXL. In addition, AXL-related tumor neoantigens were identified and might provide the novel potential targets for tumor vaccines or SARS-Cov-2 vaccines research in cancer patients.
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spelling pubmed-92340552022-06-27 Comprehensive analysis of the novel omicron receptor AXL in cancers Zhang, Wei-Na Li, Xue-Ping Wang, Peng-Fei Zhu, Lu Xiao, Xin-Hua Dai, Yu-Jun Comput Struct Biotechnol J Research Article The SARS-CoV-2 is constantly mutating, and the new coronavirus such as Omicron has spread to many countries around the world. Anexelekto (AXL) is a transmembrane protein with biological functions such as promoting cell growth, migration, aggregation, metastasis and adhesion, and plays an important role in cancers and coronavirus disease 2019 (COVID-19). Unlike angiotensin-converting enzyme 2 (ACE2), AXL was highly expressed in respiratory system cells. In this study, we verified the AXL expression in cancer and normal tissues and found AXL expression was strongly correlated with cancer prognosis, tumor mutation burden (TMB), the microsatellite instability (MSI) in most tumor types. Immune infiltration analysis also demonstrated that there was an inextricable link between AXL expression and immune scores in cancer patients, especially in BLCA, BRCA and CESC. The NK-cells, plasmacytoid dendritic cells, myeloid dendritic cells, as one of the important components of the tumor microenvironment, were highly expressed AXL. In addition, AXL-related tumor neoantigens were identified and might provide the novel potential targets for tumor vaccines or SARS-Cov-2 vaccines research in cancer patients. Research Network of Computational and Structural Biotechnology 2022-06-27 /pmc/articles/PMC9234055/ /pubmed/35782741 http://dx.doi.org/10.1016/j.csbj.2022.06.051 Text en © 2022 The Author(s) https://creativecommons.org/licenses/by/4.0/This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Research Article
Zhang, Wei-Na
Li, Xue-Ping
Wang, Peng-Fei
Zhu, Lu
Xiao, Xin-Hua
Dai, Yu-Jun
Comprehensive analysis of the novel omicron receptor AXL in cancers
title Comprehensive analysis of the novel omicron receptor AXL in cancers
title_full Comprehensive analysis of the novel omicron receptor AXL in cancers
title_fullStr Comprehensive analysis of the novel omicron receptor AXL in cancers
title_full_unstemmed Comprehensive analysis of the novel omicron receptor AXL in cancers
title_short Comprehensive analysis of the novel omicron receptor AXL in cancers
title_sort comprehensive analysis of the novel omicron receptor axl in cancers
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9234055/
https://www.ncbi.nlm.nih.gov/pubmed/35782741
http://dx.doi.org/10.1016/j.csbj.2022.06.051
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