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The effect of date seed (Phoenix dactylifera) supplementation on inflammation, oxidative stress biomarkers, and performance in active people: A blinded randomized controlled trial protocol

INTRODUCTION: High-intensity interval training (HIIT) is an efficient training method to improve vascular function, maximal oxygen consumption, and muscle mitochondrial capacity while maximizing muscular damage. Recently, functional foods have been considered a practical approach to avoiding HIIT da...

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Autores principales: Moslemi, Elham, Dehghan, Parvin, Khani, Mostafa
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9234073/
https://www.ncbi.nlm.nih.gov/pubmed/35769196
http://dx.doi.org/10.1016/j.conctc.2022.100951
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author Moslemi, Elham
Dehghan, Parvin
Khani, Mostafa
author_facet Moslemi, Elham
Dehghan, Parvin
Khani, Mostafa
author_sort Moslemi, Elham
collection PubMed
description INTRODUCTION: High-intensity interval training (HIIT) is an efficient training method to improve vascular function, maximal oxygen consumption, and muscle mitochondrial capacity while maximizing muscular damage. Recently, functional foods have been considered a practical approach to avoiding HIIT damage and improving sports performance. Thus, the present study will evaluate the effectiveness of date seed powder as a functional food on the nutritional, oxidative stress, anti/inflammatory status, mental health, and performance of active people. METHODS: This study is a double-blind, randomized, placebo-controlled trial, which will be conducted among recreational runners at Tabriz stadiums, Iran. Thirty-six recreational runners will be randomly selected into two groups to consume 26 g/d date seed powder or placebo for 14 days. Both groups will do HIIT workouts. Body composition, food intake, total antioxidant capacity (TAC), oxidative stress index (OSI), total oxidant status (TOS), superoxide dismutase (SOD), glutathione peroxidase (GPx), malondialdehyde (MDA), 8-iso-prostaglandin F2α (8-iso-PGF2α), uric acid, protein carbonyl (PC), catalase (CAT), glutathione (GSH), nitric oxide (NO), high-sensitivity C-reactive protein (hs-CRP), tumor necrosis factor-alpha (TNF-α), interleukin-6 (IL-6), interleukin-10 (IL-10), IL-6/IL-10, creatine kinase (CK), lactate dehydrogenase (LDH), myoglobin (MYO), brain-derived neurotrophic factor (BDNF), insulin-like growth factor-1 (IGF-1), irisin, cortisol, muscle pain, aerobic and anaerobic performance will be evaluated at the beginning, end of the intervention and 24 h later. ETHICS AND DISSEMINATION: This study was approved by the Medical Ethics Committee of TBZMED (No.IR.TBZMED.REC.1399.1011). This research's findings will be published in a peer-reviewed journal and presented at international conferences. TRIAL REGISTRATION: Iranian Registry of Clinical Trials website (www.IRCT.ir/, IRCT20150205020965N9).
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spelling pubmed-92340732022-06-28 The effect of date seed (Phoenix dactylifera) supplementation on inflammation, oxidative stress biomarkers, and performance in active people: A blinded randomized controlled trial protocol Moslemi, Elham Dehghan, Parvin Khani, Mostafa Contemp Clin Trials Commun Article INTRODUCTION: High-intensity interval training (HIIT) is an efficient training method to improve vascular function, maximal oxygen consumption, and muscle mitochondrial capacity while maximizing muscular damage. Recently, functional foods have been considered a practical approach to avoiding HIIT damage and improving sports performance. Thus, the present study will evaluate the effectiveness of date seed powder as a functional food on the nutritional, oxidative stress, anti/inflammatory status, mental health, and performance of active people. METHODS: This study is a double-blind, randomized, placebo-controlled trial, which will be conducted among recreational runners at Tabriz stadiums, Iran. Thirty-six recreational runners will be randomly selected into two groups to consume 26 g/d date seed powder or placebo for 14 days. Both groups will do HIIT workouts. Body composition, food intake, total antioxidant capacity (TAC), oxidative stress index (OSI), total oxidant status (TOS), superoxide dismutase (SOD), glutathione peroxidase (GPx), malondialdehyde (MDA), 8-iso-prostaglandin F2α (8-iso-PGF2α), uric acid, protein carbonyl (PC), catalase (CAT), glutathione (GSH), nitric oxide (NO), high-sensitivity C-reactive protein (hs-CRP), tumor necrosis factor-alpha (TNF-α), interleukin-6 (IL-6), interleukin-10 (IL-10), IL-6/IL-10, creatine kinase (CK), lactate dehydrogenase (LDH), myoglobin (MYO), brain-derived neurotrophic factor (BDNF), insulin-like growth factor-1 (IGF-1), irisin, cortisol, muscle pain, aerobic and anaerobic performance will be evaluated at the beginning, end of the intervention and 24 h later. ETHICS AND DISSEMINATION: This study was approved by the Medical Ethics Committee of TBZMED (No.IR.TBZMED.REC.1399.1011). This research's findings will be published in a peer-reviewed journal and presented at international conferences. TRIAL REGISTRATION: Iranian Registry of Clinical Trials website (www.IRCT.ir/, IRCT20150205020965N9). Elsevier 2022-06-13 /pmc/articles/PMC9234073/ /pubmed/35769196 http://dx.doi.org/10.1016/j.conctc.2022.100951 Text en © 2022 The Author(s) https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Article
Moslemi, Elham
Dehghan, Parvin
Khani, Mostafa
The effect of date seed (Phoenix dactylifera) supplementation on inflammation, oxidative stress biomarkers, and performance in active people: A blinded randomized controlled trial protocol
title The effect of date seed (Phoenix dactylifera) supplementation on inflammation, oxidative stress biomarkers, and performance in active people: A blinded randomized controlled trial protocol
title_full The effect of date seed (Phoenix dactylifera) supplementation on inflammation, oxidative stress biomarkers, and performance in active people: A blinded randomized controlled trial protocol
title_fullStr The effect of date seed (Phoenix dactylifera) supplementation on inflammation, oxidative stress biomarkers, and performance in active people: A blinded randomized controlled trial protocol
title_full_unstemmed The effect of date seed (Phoenix dactylifera) supplementation on inflammation, oxidative stress biomarkers, and performance in active people: A blinded randomized controlled trial protocol
title_short The effect of date seed (Phoenix dactylifera) supplementation on inflammation, oxidative stress biomarkers, and performance in active people: A blinded randomized controlled trial protocol
title_sort effect of date seed (phoenix dactylifera) supplementation on inflammation, oxidative stress biomarkers, and performance in active people: a blinded randomized controlled trial protocol
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9234073/
https://www.ncbi.nlm.nih.gov/pubmed/35769196
http://dx.doi.org/10.1016/j.conctc.2022.100951
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