B10 Cells Are Associated With Clinical Prognosis During Adult Symptomatic Acute HBV Infection

There are few reports about the role of B10 cells in acute hepatitis B (AHB) infection. In this study, based on 48 acute hepatitis B infected patients, we analysis the correlation of B10 cells with HBV clinical prognosis. The results showed that B10 was positively correlated with HBsAg and HBeAg and...

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Autores principales: Liu, Yali, Du, Xiaofei, Lu, Junfeng, Ma, Lina, Jing, Yi, Ben, Haijing, Chen, Xinyue, Zhang, Jing
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9234142/
https://www.ncbi.nlm.nih.gov/pubmed/35769476
http://dx.doi.org/10.3389/fimmu.2022.906650
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author Liu, Yali
Du, Xiaofei
Lu, Junfeng
Ma, Lina
Jing, Yi
Ben, Haijing
Chen, Xinyue
Zhang, Jing
author_facet Liu, Yali
Du, Xiaofei
Lu, Junfeng
Ma, Lina
Jing, Yi
Ben, Haijing
Chen, Xinyue
Zhang, Jing
author_sort Liu, Yali
collection PubMed
description There are few reports about the role of B10 cells in acute hepatitis B (AHB) infection. In this study, based on 48 acute hepatitis B infected patients, we analysis the correlation of B10 cells with HBV clinical prognosis. The results showed that B10 was positively correlated with HBsAg and HBeAg and inversely correlated with anti-HBs. The level of B10 in one week before HBsAg clearance was significantly lower than 2 weeks prior to HBsAg clearance and after 1-2 weeks of HBsAg clearance. B10 cell frequency displayed no correlation with HBV DNA; however, it showed significant temporal synchronization with hepatic inflammatory markers such as ALT. B10 level also associated with hospitalization time. These results indicated that B10 is closely related to the clinical prognosis of acute HBV infection.
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spelling pubmed-92341422022-06-28 B10 Cells Are Associated With Clinical Prognosis During Adult Symptomatic Acute HBV Infection Liu, Yali Du, Xiaofei Lu, Junfeng Ma, Lina Jing, Yi Ben, Haijing Chen, Xinyue Zhang, Jing Front Immunol Immunology There are few reports about the role of B10 cells in acute hepatitis B (AHB) infection. In this study, based on 48 acute hepatitis B infected patients, we analysis the correlation of B10 cells with HBV clinical prognosis. The results showed that B10 was positively correlated with HBsAg and HBeAg and inversely correlated with anti-HBs. The level of B10 in one week before HBsAg clearance was significantly lower than 2 weeks prior to HBsAg clearance and after 1-2 weeks of HBsAg clearance. B10 cell frequency displayed no correlation with HBV DNA; however, it showed significant temporal synchronization with hepatic inflammatory markers such as ALT. B10 level also associated with hospitalization time. These results indicated that B10 is closely related to the clinical prognosis of acute HBV infection. Frontiers Media S.A. 2022-06-13 /pmc/articles/PMC9234142/ /pubmed/35769476 http://dx.doi.org/10.3389/fimmu.2022.906650 Text en Copyright © 2022 Liu, Du, Lu, Ma, Jing, Ben, Chen and Zhang https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Immunology
Liu, Yali
Du, Xiaofei
Lu, Junfeng
Ma, Lina
Jing, Yi
Ben, Haijing
Chen, Xinyue
Zhang, Jing
B10 Cells Are Associated With Clinical Prognosis During Adult Symptomatic Acute HBV Infection
title B10 Cells Are Associated With Clinical Prognosis During Adult Symptomatic Acute HBV Infection
title_full B10 Cells Are Associated With Clinical Prognosis During Adult Symptomatic Acute HBV Infection
title_fullStr B10 Cells Are Associated With Clinical Prognosis During Adult Symptomatic Acute HBV Infection
title_full_unstemmed B10 Cells Are Associated With Clinical Prognosis During Adult Symptomatic Acute HBV Infection
title_short B10 Cells Are Associated With Clinical Prognosis During Adult Symptomatic Acute HBV Infection
title_sort b10 cells are associated with clinical prognosis during adult symptomatic acute hbv infection
topic Immunology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9234142/
https://www.ncbi.nlm.nih.gov/pubmed/35769476
http://dx.doi.org/10.3389/fimmu.2022.906650
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