Fringe GlcNAc-transferases differentially extend O-fucose on endogenous NOTCH1 in mouse activated T cells

NOTCH1 is a transmembrane receptor that initiates a cell–cell signaling pathway controlling various cell fate specifications in metazoans. The addition of O-fucose by protein O-fucosyltransferase 1 (POFUT1) to epidermal growth factor-like (EGF) repeats in the NOTCH1 extracellular domain is essential...

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Detalles Bibliográficos
Autores principales: Matsumoto, Kenjiroo, Kumar, Vivek, Varshney, Shweta, Nairn, Alison V., Ito, Atsuko, Pennarubia, Florian, Moremen, Kelley W., Stanley, Pamela, Haltiwanger, Robert S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9234238/
https://www.ncbi.nlm.nih.gov/pubmed/35623385
http://dx.doi.org/10.1016/j.jbc.2022.102064

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