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Alteration of Peripheral Resistin and the Severity of Acute Pancreatitis: A Meta-Analysis

INTRODUCTION: Resistin is a small secretory adipokine which is implicated to obesity and associated diseases. Recently, plenty of research papers have been conducted to explore the association between peripheral resistin and the severity of acute pancreatitis (AP). However, the results were controve...

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Autores principales: Yang, Jianhua, Liu, Mengyao, Wang, Shu, Gan, Yuanxiu, Chen, Xiangyu, Tao, Yang, Gao, Junwei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9234264/
https://www.ncbi.nlm.nih.gov/pubmed/35770007
http://dx.doi.org/10.3389/fmed.2022.915152
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author Yang, Jianhua
Liu, Mengyao
Wang, Shu
Gan, Yuanxiu
Chen, Xiangyu
Tao, Yang
Gao, Junwei
author_facet Yang, Jianhua
Liu, Mengyao
Wang, Shu
Gan, Yuanxiu
Chen, Xiangyu
Tao, Yang
Gao, Junwei
author_sort Yang, Jianhua
collection PubMed
description INTRODUCTION: Resistin is a small secretory adipokine which is implicated to obesity and associated diseases. Recently, plenty of research papers have been conducted to explore the association between peripheral resistin and the severity of acute pancreatitis (AP). However, the results were controversial. In this study, we aimed to confirm the effect of peripheral resistin and the development of acute pancreatitis. METHODS: A comprehensive online search was performed using the PubMed, Embase, Web of Science, CNKI, and Wanfang databases up through January 20, 2022. The retrieved records and their references were screened to identify additional studies. Data were extracted to calculate the pooled Hedges' g and its 95% CI, which were selected to assess peripheral resistin levels and the severity of acute pancreatitis. Subgroup analyses, sensitivity analyses, meta-regression, and publication bias tests were also undertaken based on obtained information. RESULTS: A total of eleven studies with 892 acute pancreatitis patients were enrolled in the study. Peripheral resistin levels were significantly increased in severe acute pancreatitis compared with mild acute pancreatitis (Hedges' g = 2.092, 95% CI: 0.994–3.190, P < 0.001). Subgroup analyses based on sample types and ethnicity also showed similar results. A single study did not affect our results, which was verified by sensitivity analysis. Meta-regression analyses revealed that age, gender of the included subjects, sample size, and publication year did not moderate effects on the present results. CONCLUSION: In our study, peripheral resistin levels were significantly elevated in patients with severe AP compared with patients with mild AP. Abnormal resistin levels may provide us some new insights in predicting the severity of AP.
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spelling pubmed-92342642022-06-28 Alteration of Peripheral Resistin and the Severity of Acute Pancreatitis: A Meta-Analysis Yang, Jianhua Liu, Mengyao Wang, Shu Gan, Yuanxiu Chen, Xiangyu Tao, Yang Gao, Junwei Front Med (Lausanne) Medicine INTRODUCTION: Resistin is a small secretory adipokine which is implicated to obesity and associated diseases. Recently, plenty of research papers have been conducted to explore the association between peripheral resistin and the severity of acute pancreatitis (AP). However, the results were controversial. In this study, we aimed to confirm the effect of peripheral resistin and the development of acute pancreatitis. METHODS: A comprehensive online search was performed using the PubMed, Embase, Web of Science, CNKI, and Wanfang databases up through January 20, 2022. The retrieved records and their references were screened to identify additional studies. Data were extracted to calculate the pooled Hedges' g and its 95% CI, which were selected to assess peripheral resistin levels and the severity of acute pancreatitis. Subgroup analyses, sensitivity analyses, meta-regression, and publication bias tests were also undertaken based on obtained information. RESULTS: A total of eleven studies with 892 acute pancreatitis patients were enrolled in the study. Peripheral resistin levels were significantly increased in severe acute pancreatitis compared with mild acute pancreatitis (Hedges' g = 2.092, 95% CI: 0.994–3.190, P < 0.001). Subgroup analyses based on sample types and ethnicity also showed similar results. A single study did not affect our results, which was verified by sensitivity analysis. Meta-regression analyses revealed that age, gender of the included subjects, sample size, and publication year did not moderate effects on the present results. CONCLUSION: In our study, peripheral resistin levels were significantly elevated in patients with severe AP compared with patients with mild AP. Abnormal resistin levels may provide us some new insights in predicting the severity of AP. Frontiers Media S.A. 2022-06-13 /pmc/articles/PMC9234264/ /pubmed/35770007 http://dx.doi.org/10.3389/fmed.2022.915152 Text en Copyright © 2022 Yang, Liu, Wang, Gan, Chen, Tao and Gao. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Medicine
Yang, Jianhua
Liu, Mengyao
Wang, Shu
Gan, Yuanxiu
Chen, Xiangyu
Tao, Yang
Gao, Junwei
Alteration of Peripheral Resistin and the Severity of Acute Pancreatitis: A Meta-Analysis
title Alteration of Peripheral Resistin and the Severity of Acute Pancreatitis: A Meta-Analysis
title_full Alteration of Peripheral Resistin and the Severity of Acute Pancreatitis: A Meta-Analysis
title_fullStr Alteration of Peripheral Resistin and the Severity of Acute Pancreatitis: A Meta-Analysis
title_full_unstemmed Alteration of Peripheral Resistin and the Severity of Acute Pancreatitis: A Meta-Analysis
title_short Alteration of Peripheral Resistin and the Severity of Acute Pancreatitis: A Meta-Analysis
title_sort alteration of peripheral resistin and the severity of acute pancreatitis: a meta-analysis
topic Medicine
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9234264/
https://www.ncbi.nlm.nih.gov/pubmed/35770007
http://dx.doi.org/10.3389/fmed.2022.915152
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