Telomere Attrition in Induced Pluripotent Stem Cell-Derived Neurons From ALS/FTD-Related C9ORF72 Repeat Expansion Carriers

The GGGGCC (G4C2) repeat expansion in C9ORF72 is the most common genetic cause of amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). Dysregulated DNA damage response and the generation of reactive oxygen species (ROS) have been postulated as major drivers of toxicity in C9ORF72 p...

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Detalles Bibliográficos
Autores principales: Robinson, Hayley, Ali, Sk Imran, Diaz-Hernandez, Martha Elena, Lopez-Gonzalez, Rodrigo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Cell and Developmental Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9234284/
https://www.ncbi.nlm.nih.gov/pubmed/35769259
http://dx.doi.org/10.3389/fcell.2022.874323

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9234284/
https://www.ncbi.nlm.nih.gov/pubmed/35769259
http://dx.doi.org/10.3389/fcell.2022.874323

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