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Biological Characteristics of HLA-G and Its Role in Solid Organ Transplantation

Organ transplantation is a lifesaving option for patients with advanced diseases. Rejection is regarded as one of the most severe risk factors post-transplantation. A molecule that contributes to immune tolerance and resisting rejection is human leukocyte antigen (HLA)-G, which belongs to the non-cl...

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Autores principales: Liu, Siqi, Bos, Nicolaas A., Verschuuren, Erik A. M., van Baarle, Debbie, Westra, Johanna
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9234285/
https://www.ncbi.nlm.nih.gov/pubmed/35769475
http://dx.doi.org/10.3389/fimmu.2022.902093
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author Liu, Siqi
Bos, Nicolaas A.
Verschuuren, Erik A. M.
van Baarle, Debbie
Westra, Johanna
author_facet Liu, Siqi
Bos, Nicolaas A.
Verschuuren, Erik A. M.
van Baarle, Debbie
Westra, Johanna
author_sort Liu, Siqi
collection PubMed
description Organ transplantation is a lifesaving option for patients with advanced diseases. Rejection is regarded as one of the most severe risk factors post-transplantation. A molecule that contributes to immune tolerance and resisting rejection is human leukocyte antigen (HLA)-G, which belongs to the non-classical major histocompatibility complex class (MHC) I family. HLA-G was originally found to play a role during pregnancy to maintain immune tolerance between mother and child. It is expressed in the placenta and detected in several body fluids as soluble factor as well as different membrane isoforms on cells. Recent findings on HLA-G show that it can also play multifaceted roles during transplantation. This review will explain the general characteristics and biological function of HLA-G and summarize the views supporting the tolerogenic and other roles of HLA-G to better understand its role in solid organ transplantation (SOT) and its complications. Finally, we will discuss potential future research on the role of HLA-G in prevention, diagnosis, and treatment in SOT.
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spelling pubmed-92342852022-06-28 Biological Characteristics of HLA-G and Its Role in Solid Organ Transplantation Liu, Siqi Bos, Nicolaas A. Verschuuren, Erik A. M. van Baarle, Debbie Westra, Johanna Front Immunol Immunology Organ transplantation is a lifesaving option for patients with advanced diseases. Rejection is regarded as one of the most severe risk factors post-transplantation. A molecule that contributes to immune tolerance and resisting rejection is human leukocyte antigen (HLA)-G, which belongs to the non-classical major histocompatibility complex class (MHC) I family. HLA-G was originally found to play a role during pregnancy to maintain immune tolerance between mother and child. It is expressed in the placenta and detected in several body fluids as soluble factor as well as different membrane isoforms on cells. Recent findings on HLA-G show that it can also play multifaceted roles during transplantation. This review will explain the general characteristics and biological function of HLA-G and summarize the views supporting the tolerogenic and other roles of HLA-G to better understand its role in solid organ transplantation (SOT) and its complications. Finally, we will discuss potential future research on the role of HLA-G in prevention, diagnosis, and treatment in SOT. Frontiers Media S.A. 2022-06-13 /pmc/articles/PMC9234285/ /pubmed/35769475 http://dx.doi.org/10.3389/fimmu.2022.902093 Text en Copyright © 2022 Liu, Bos, Verschuuren, van Baarle and Westra https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Immunology
Liu, Siqi
Bos, Nicolaas A.
Verschuuren, Erik A. M.
van Baarle, Debbie
Westra, Johanna
Biological Characteristics of HLA-G and Its Role in Solid Organ Transplantation
title Biological Characteristics of HLA-G and Its Role in Solid Organ Transplantation
title_full Biological Characteristics of HLA-G and Its Role in Solid Organ Transplantation
title_fullStr Biological Characteristics of HLA-G and Its Role in Solid Organ Transplantation
title_full_unstemmed Biological Characteristics of HLA-G and Its Role in Solid Organ Transplantation
title_short Biological Characteristics of HLA-G and Its Role in Solid Organ Transplantation
title_sort biological characteristics of hla-g and its role in solid organ transplantation
topic Immunology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9234285/
https://www.ncbi.nlm.nih.gov/pubmed/35769475
http://dx.doi.org/10.3389/fimmu.2022.902093
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