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Follicular Fluid Growth Factors and Interleukin Profiling as Potential Predictors of IVF Outcomes
Growth hormone (GH) has gained attention as an anti-aging compound enhancing oocyte quality. In fact, GH is known to activate intrafollicular metabolic events for oocyte maturation. Insulin growth factor I (IGF1) is another ovarian growth factor that mediates the FSH and GH actions. Cytokines could...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9234297/ https://www.ncbi.nlm.nih.gov/pubmed/35770187 http://dx.doi.org/10.3389/fphys.2022.859790 |
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author | Molka, Bouricha Gwladys, Bourdenet Dorian, Bosquet Lucie, Moussot Mustapha, Benkhalifa Rosalie, Cabry Brigitte, Gubler Hafida, Khorsi-Cauet Moncef, Benkhalifa |
author_facet | Molka, Bouricha Gwladys, Bourdenet Dorian, Bosquet Lucie, Moussot Mustapha, Benkhalifa Rosalie, Cabry Brigitte, Gubler Hafida, Khorsi-Cauet Moncef, Benkhalifa |
author_sort | Molka, Bouricha |
collection | PubMed |
description | Growth hormone (GH) has gained attention as an anti-aging compound enhancing oocyte quality. In fact, GH is known to activate intrafollicular metabolic events for oocyte maturation. Insulin growth factor I (IGF1) is another ovarian growth factor that mediates the FSH and GH actions. Cytokines could also increase IVF outcomes. Indeed, IL-6 is a pleiotropic cytokine with multiple cellular effects that can vary based on the physiological environment. IL-6 may also play an important role in follicular development (Yang et al., J Assist Reprod Genet, 2020, 37 (5), 1171–1176). Clinical studies have been performed to explore the potential role of IL-6 in human oocyte maturation and subsequent embryonic development. To date, the answers are not conclusive. During peri-implantation, many cytokines balances are regulated like pro-inflammatory and anti-inflammatory interleukins. The pro-inflammatory properties of IL-17 and its impact on the tumor microenvironment or autoimmune diseases are characterized, but new dimensions of IL-17 activity that promotes embryo implantation are not well explored. In the search for answers, our study compared concentrations of growth factors IGF1, GH, and interleukins IL-6 and IL-17 in the follicular fluid (FF) from 140 women divided into two groups depending on bad (G1) or good prognosis (G2) and investigated the relationships between these FF components’ levels and the main parameters of IVF. GH, IGF1, and IL-6 were significantly higher for G2. For GH, it was negatively correlated to patient age and positively correlated to maturity rate and IGF1. Moreover, GH and IGF1 were correlated to the top embryo rate and cumulative pregnancy rate. Regarding IL-6, it was correlated to IGF1 level, endometrium thickness, and implantation rate. As for IL-17, it was only correlated to IL-6. Consequently, all these FF components were predictive of oocyte quality except IL-17. GH seemed to be the best biomarker of this quality. |
format | Online Article Text |
id | pubmed-9234297 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-92342972022-06-28 Follicular Fluid Growth Factors and Interleukin Profiling as Potential Predictors of IVF Outcomes Molka, Bouricha Gwladys, Bourdenet Dorian, Bosquet Lucie, Moussot Mustapha, Benkhalifa Rosalie, Cabry Brigitte, Gubler Hafida, Khorsi-Cauet Moncef, Benkhalifa Front Physiol Physiology Growth hormone (GH) has gained attention as an anti-aging compound enhancing oocyte quality. In fact, GH is known to activate intrafollicular metabolic events for oocyte maturation. Insulin growth factor I (IGF1) is another ovarian growth factor that mediates the FSH and GH actions. Cytokines could also increase IVF outcomes. Indeed, IL-6 is a pleiotropic cytokine with multiple cellular effects that can vary based on the physiological environment. IL-6 may also play an important role in follicular development (Yang et al., J Assist Reprod Genet, 2020, 37 (5), 1171–1176). Clinical studies have been performed to explore the potential role of IL-6 in human oocyte maturation and subsequent embryonic development. To date, the answers are not conclusive. During peri-implantation, many cytokines balances are regulated like pro-inflammatory and anti-inflammatory interleukins. The pro-inflammatory properties of IL-17 and its impact on the tumor microenvironment or autoimmune diseases are characterized, but new dimensions of IL-17 activity that promotes embryo implantation are not well explored. In the search for answers, our study compared concentrations of growth factors IGF1, GH, and interleukins IL-6 and IL-17 in the follicular fluid (FF) from 140 women divided into two groups depending on bad (G1) or good prognosis (G2) and investigated the relationships between these FF components’ levels and the main parameters of IVF. GH, IGF1, and IL-6 were significantly higher for G2. For GH, it was negatively correlated to patient age and positively correlated to maturity rate and IGF1. Moreover, GH and IGF1 were correlated to the top embryo rate and cumulative pregnancy rate. Regarding IL-6, it was correlated to IGF1 level, endometrium thickness, and implantation rate. As for IL-17, it was only correlated to IL-6. Consequently, all these FF components were predictive of oocyte quality except IL-17. GH seemed to be the best biomarker of this quality. Frontiers Media S.A. 2022-06-13 /pmc/articles/PMC9234297/ /pubmed/35770187 http://dx.doi.org/10.3389/fphys.2022.859790 Text en Copyright © 2022 Molka, Gwladys, Dorian, Lucie, Mustapha, Rosalie, Brigitte, Hafida and Moncef. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Physiology Molka, Bouricha Gwladys, Bourdenet Dorian, Bosquet Lucie, Moussot Mustapha, Benkhalifa Rosalie, Cabry Brigitte, Gubler Hafida, Khorsi-Cauet Moncef, Benkhalifa Follicular Fluid Growth Factors and Interleukin Profiling as Potential Predictors of IVF Outcomes |
title | Follicular Fluid Growth Factors and Interleukin Profiling as Potential Predictors of IVF Outcomes |
title_full | Follicular Fluid Growth Factors and Interleukin Profiling as Potential Predictors of IVF Outcomes |
title_fullStr | Follicular Fluid Growth Factors and Interleukin Profiling as Potential Predictors of IVF Outcomes |
title_full_unstemmed | Follicular Fluid Growth Factors and Interleukin Profiling as Potential Predictors of IVF Outcomes |
title_short | Follicular Fluid Growth Factors and Interleukin Profiling as Potential Predictors of IVF Outcomes |
title_sort | follicular fluid growth factors and interleukin profiling as potential predictors of ivf outcomes |
topic | Physiology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9234297/ https://www.ncbi.nlm.nih.gov/pubmed/35770187 http://dx.doi.org/10.3389/fphys.2022.859790 |
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