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Three Physiological Components That Influence Regional Cerebral Tissue Oxygen Saturation
Near-infrared spectroscopy (NIRS) measurement of regional cerebral tissue oxygen saturation (rcStO2) has become a topic of high interest in neonatology. Multiple studies have demonstrated that rcStO2 measurements are feasible in the delivery room during immediate transition and resuscitation as well...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9234387/ https://www.ncbi.nlm.nih.gov/pubmed/35769216 http://dx.doi.org/10.3389/fped.2022.913223 |
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author | Suppan, Ena Pichler, Gerhard Binder-Heschl, Corinna Schwaberger, Bernhard Urlesberger, Berndt |
author_facet | Suppan, Ena Pichler, Gerhard Binder-Heschl, Corinna Schwaberger, Bernhard Urlesberger, Berndt |
author_sort | Suppan, Ena |
collection | PubMed |
description | Near-infrared spectroscopy (NIRS) measurement of regional cerebral tissue oxygen saturation (rcStO2) has become a topic of high interest in neonatology. Multiple studies have demonstrated that rcStO2 measurements are feasible in the delivery room during immediate transition and resuscitation as well as after admission to the neonatal intensive care unit. Reference ranges for different gestational ages, modes of delivery, and devices have already been published. RcStO2 reflects a mixed tissue saturation, composed of arterial (A), venous (V), and capillary signals, derived from small vessels within the measurement compartment. The A:V signal ratio fluctuates based on changes in oxygen delivery and oxygen consumption, which enables a reliable trend monitoring of the balance between these two parameters. While the increasing research evidence supports its use, the interpretation of the absolute values of and trends in rcStO2 is still challenging, which halts its routine use in the delivery room and at the bedside. To visualize the influencing factors and improve the understanding of rcStO2 values, we have created a flowchart, which focuses on the three major physiological components that affect rcStO2: oxygen content, circulation, and oxygen extraction. Each of these has its defining parameters, which are discussed in detail in each section. |
format | Online Article Text |
id | pubmed-9234387 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-92343872022-06-28 Three Physiological Components That Influence Regional Cerebral Tissue Oxygen Saturation Suppan, Ena Pichler, Gerhard Binder-Heschl, Corinna Schwaberger, Bernhard Urlesberger, Berndt Front Pediatr Pediatrics Near-infrared spectroscopy (NIRS) measurement of regional cerebral tissue oxygen saturation (rcStO2) has become a topic of high interest in neonatology. Multiple studies have demonstrated that rcStO2 measurements are feasible in the delivery room during immediate transition and resuscitation as well as after admission to the neonatal intensive care unit. Reference ranges for different gestational ages, modes of delivery, and devices have already been published. RcStO2 reflects a mixed tissue saturation, composed of arterial (A), venous (V), and capillary signals, derived from small vessels within the measurement compartment. The A:V signal ratio fluctuates based on changes in oxygen delivery and oxygen consumption, which enables a reliable trend monitoring of the balance between these two parameters. While the increasing research evidence supports its use, the interpretation of the absolute values of and trends in rcStO2 is still challenging, which halts its routine use in the delivery room and at the bedside. To visualize the influencing factors and improve the understanding of rcStO2 values, we have created a flowchart, which focuses on the three major physiological components that affect rcStO2: oxygen content, circulation, and oxygen extraction. Each of these has its defining parameters, which are discussed in detail in each section. Frontiers Media S.A. 2022-06-13 /pmc/articles/PMC9234387/ /pubmed/35769216 http://dx.doi.org/10.3389/fped.2022.913223 Text en Copyright © 2022 Suppan, Pichler, Binder-Heschl, Schwaberger and Urlesberger. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Pediatrics Suppan, Ena Pichler, Gerhard Binder-Heschl, Corinna Schwaberger, Bernhard Urlesberger, Berndt Three Physiological Components That Influence Regional Cerebral Tissue Oxygen Saturation |
title | Three Physiological Components That Influence Regional Cerebral Tissue Oxygen Saturation |
title_full | Three Physiological Components That Influence Regional Cerebral Tissue Oxygen Saturation |
title_fullStr | Three Physiological Components That Influence Regional Cerebral Tissue Oxygen Saturation |
title_full_unstemmed | Three Physiological Components That Influence Regional Cerebral Tissue Oxygen Saturation |
title_short | Three Physiological Components That Influence Regional Cerebral Tissue Oxygen Saturation |
title_sort | three physiological components that influence regional cerebral tissue oxygen saturation |
topic | Pediatrics |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9234387/ https://www.ncbi.nlm.nih.gov/pubmed/35769216 http://dx.doi.org/10.3389/fped.2022.913223 |
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