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Diabetes and SARS-CoV-2–Is There a Mutual Connection?
SARS-CoV-2, a newly emerged virus described for the first time in late 2019, affects multiple organs in humans, including the pancreas. Here, we present the bilateral link between the pathophysiology of diabetes and COVID-19, with diabetes being COVID-19 comorbidity, and a complication of SARS-CoV-2...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9234398/ https://www.ncbi.nlm.nih.gov/pubmed/35769263 http://dx.doi.org/10.3389/fcell.2022.913305 |
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author | Jedrzejak, Anna P. Urbaniak, Edyta K. Wasko, Jadwiga A. Ziojla, Natalia Borowiak, Malgorzata |
author_facet | Jedrzejak, Anna P. Urbaniak, Edyta K. Wasko, Jadwiga A. Ziojla, Natalia Borowiak, Malgorzata |
author_sort | Jedrzejak, Anna P. |
collection | PubMed |
description | SARS-CoV-2, a newly emerged virus described for the first time in late 2019, affects multiple organs in humans, including the pancreas. Here, we present the bilateral link between the pathophysiology of diabetes and COVID-19, with diabetes being COVID-19 comorbidity, and a complication of SARS-CoV-2 infection. Analysis of clinical data indicates that patients with chronic conditions like diabetes are at increased risk of severe COVID-19, hospitalization, ICU admission, and death compared to the healthy subjects. Further, we show that SARS-CoV-2 infection might be also associated with the development of new-onset diabetes and diabetic ketoacidosis. We then discuss the options for studying SARS-CoV-2 infection in pancreatic settings, including the use of human pluripotent stem cell-derived pancreatic organoids. Further, we review the presence of SARS-CoV-2 receptors in different pancreatic cell types and the infection efficiency based on pancreatic sections from COVID-19 patients and primary human islet in vitro studies. Finally, we discuss the impact of SARS-CoV-2 infection on human pancreatic cell homeostasis, focusing on β-cells. |
format | Online Article Text |
id | pubmed-9234398 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-92343982022-06-28 Diabetes and SARS-CoV-2–Is There a Mutual Connection? Jedrzejak, Anna P. Urbaniak, Edyta K. Wasko, Jadwiga A. Ziojla, Natalia Borowiak, Malgorzata Front Cell Dev Biol Cell and Developmental Biology SARS-CoV-2, a newly emerged virus described for the first time in late 2019, affects multiple organs in humans, including the pancreas. Here, we present the bilateral link between the pathophysiology of diabetes and COVID-19, with diabetes being COVID-19 comorbidity, and a complication of SARS-CoV-2 infection. Analysis of clinical data indicates that patients with chronic conditions like diabetes are at increased risk of severe COVID-19, hospitalization, ICU admission, and death compared to the healthy subjects. Further, we show that SARS-CoV-2 infection might be also associated with the development of new-onset diabetes and diabetic ketoacidosis. We then discuss the options for studying SARS-CoV-2 infection in pancreatic settings, including the use of human pluripotent stem cell-derived pancreatic organoids. Further, we review the presence of SARS-CoV-2 receptors in different pancreatic cell types and the infection efficiency based on pancreatic sections from COVID-19 patients and primary human islet in vitro studies. Finally, we discuss the impact of SARS-CoV-2 infection on human pancreatic cell homeostasis, focusing on β-cells. Frontiers Media S.A. 2022-06-13 /pmc/articles/PMC9234398/ /pubmed/35769263 http://dx.doi.org/10.3389/fcell.2022.913305 Text en Copyright © 2022 Jedrzejak, Urbaniak, Wasko, Ziojla and Borowiak. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Cell and Developmental Biology Jedrzejak, Anna P. Urbaniak, Edyta K. Wasko, Jadwiga A. Ziojla, Natalia Borowiak, Malgorzata Diabetes and SARS-CoV-2–Is There a Mutual Connection? |
title | Diabetes and SARS-CoV-2–Is There a Mutual Connection? |
title_full | Diabetes and SARS-CoV-2–Is There a Mutual Connection? |
title_fullStr | Diabetes and SARS-CoV-2–Is There a Mutual Connection? |
title_full_unstemmed | Diabetes and SARS-CoV-2–Is There a Mutual Connection? |
title_short | Diabetes and SARS-CoV-2–Is There a Mutual Connection? |
title_sort | diabetes and sars-cov-2–is there a mutual connection? |
topic | Cell and Developmental Biology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9234398/ https://www.ncbi.nlm.nih.gov/pubmed/35769263 http://dx.doi.org/10.3389/fcell.2022.913305 |
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