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Diversity and Biogeography of Human Oral Saliva Microbial Communities Revealed by the Earth Microbiome Project

The oral cavity is an important window for microbial communication between the environment and the human body. The oral microbiome plays an important role in human health. However, compared to the gut microbiome, the oral microbiome has been poorly explored. Here, we analyzed 404 datasets from human...

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Autores principales: Wang, Jinlan, Feng, Jianqing, Zhu, Yongbao, Li, Dandan, Wang, Jianing, Chi, Weiwei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9234457/
https://www.ncbi.nlm.nih.gov/pubmed/35770164
http://dx.doi.org/10.3389/fmicb.2022.931065
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author Wang, Jinlan
Feng, Jianqing
Zhu, Yongbao
Li, Dandan
Wang, Jianing
Chi, Weiwei
author_facet Wang, Jinlan
Feng, Jianqing
Zhu, Yongbao
Li, Dandan
Wang, Jianing
Chi, Weiwei
author_sort Wang, Jinlan
collection PubMed
description The oral cavity is an important window for microbial communication between the environment and the human body. The oral microbiome plays an important role in human health. However, compared to the gut microbiome, the oral microbiome has been poorly explored. Here, we analyzed 404 datasets from human oral saliva samples published by the Earth Microbiome Project (EMP) and compared them with 815 samples from the human gut, nose/pharynx, and skin. The diversity of the human saliva microbiome varied significantly among individuals, and the community compositions were complex and diverse. The saliva microbiome showed the lowest species diversity among the four environment types. Human oral habitats shared a small core bacterial community containing only 14 operational taxonomic units (OTUs) under 5 phyla, which occupied over 75% of the sequence abundance. For the four habitats, the core taxa of the saliva microbiome had the greatest impact on saliva habitats than other habitats and were mostly unique. In addition, the saliva microbiome showed significant differences in the populations of different regions, which may be determined by the living environment and lifestyle/dietary habits. Finally, the correlation analysis showed high similarity between the saliva microbiome and the microbiomes of Aerosol (non-saline) and Surface (non-saline), i.e., two environment types closely related to human, suggesting that contact and shared environment being the driving factors of microbial transmission. Together, these findings expand our understanding of human oral diversity and biogeography.
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spelling pubmed-92344572022-06-28 Diversity and Biogeography of Human Oral Saliva Microbial Communities Revealed by the Earth Microbiome Project Wang, Jinlan Feng, Jianqing Zhu, Yongbao Li, Dandan Wang, Jianing Chi, Weiwei Front Microbiol Microbiology The oral cavity is an important window for microbial communication between the environment and the human body. The oral microbiome plays an important role in human health. However, compared to the gut microbiome, the oral microbiome has been poorly explored. Here, we analyzed 404 datasets from human oral saliva samples published by the Earth Microbiome Project (EMP) and compared them with 815 samples from the human gut, nose/pharynx, and skin. The diversity of the human saliva microbiome varied significantly among individuals, and the community compositions were complex and diverse. The saliva microbiome showed the lowest species diversity among the four environment types. Human oral habitats shared a small core bacterial community containing only 14 operational taxonomic units (OTUs) under 5 phyla, which occupied over 75% of the sequence abundance. For the four habitats, the core taxa of the saliva microbiome had the greatest impact on saliva habitats than other habitats and were mostly unique. In addition, the saliva microbiome showed significant differences in the populations of different regions, which may be determined by the living environment and lifestyle/dietary habits. Finally, the correlation analysis showed high similarity between the saliva microbiome and the microbiomes of Aerosol (non-saline) and Surface (non-saline), i.e., two environment types closely related to human, suggesting that contact and shared environment being the driving factors of microbial transmission. Together, these findings expand our understanding of human oral diversity and biogeography. Frontiers Media S.A. 2022-06-13 /pmc/articles/PMC9234457/ /pubmed/35770164 http://dx.doi.org/10.3389/fmicb.2022.931065 Text en Copyright © 2022 Wang, Feng, Zhu, Li, Wang and Chi. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Microbiology
Wang, Jinlan
Feng, Jianqing
Zhu, Yongbao
Li, Dandan
Wang, Jianing
Chi, Weiwei
Diversity and Biogeography of Human Oral Saliva Microbial Communities Revealed by the Earth Microbiome Project
title Diversity and Biogeography of Human Oral Saliva Microbial Communities Revealed by the Earth Microbiome Project
title_full Diversity and Biogeography of Human Oral Saliva Microbial Communities Revealed by the Earth Microbiome Project
title_fullStr Diversity and Biogeography of Human Oral Saliva Microbial Communities Revealed by the Earth Microbiome Project
title_full_unstemmed Diversity and Biogeography of Human Oral Saliva Microbial Communities Revealed by the Earth Microbiome Project
title_short Diversity and Biogeography of Human Oral Saliva Microbial Communities Revealed by the Earth Microbiome Project
title_sort diversity and biogeography of human oral saliva microbial communities revealed by the earth microbiome project
topic Microbiology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9234457/
https://www.ncbi.nlm.nih.gov/pubmed/35770164
http://dx.doi.org/10.3389/fmicb.2022.931065
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