A Murine Point Mutation of Sgpl1 Skin Is Enriched With Vγ6 IL17-Producing Cell and Revealed With Hyperpigmentation After Imiquimod Treatment

Sphingosine-1-phosphate lyase is encoded by the Sgpl1 gene, degrades S1P, and is crucial for S1P homeostasis in animal models and humans. S1P lyase deficient patients suffer from adrenal insufficiency, severe lymphopenia, and skin disorders. In this study, we used random mutagenesis screening to ide...

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Detalles Bibliográficos
Autores principales: Yang, Wenyi, Zhou, Binhui, Liu, Qi, Liu, Taozhen, Wang, Huijie, Zhang, Pei, Lu, Liaoxun, Zhang, Lichen, Zhang, Fanghui, Huang, Rong, Zhou, Jitong, Chao, Tianzhu, Gu, Yanrong, Lee, Songhua, Wang, Hui, Liang, Yinming, He, Le
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9234551/
https://www.ncbi.nlm.nih.gov/pubmed/35769463
http://dx.doi.org/10.3389/fimmu.2022.728455

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