The exploration of bio-inspired copper oxide nanoparticles: synthesis, characterization and in-vitro biological investigations

The paper describes the synthesis and characterization of copper oxide nanoparticles (CuO NPs) using the mixture of plant rhizome extracts Ocimum sanctum and Saussurea lappa as a reducing agent. The prepared CuO nanoparticles are characterized and confirmed their formation based on data obtained fro...

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Detalles Bibliográficos
Autores principales: Kolahalam, Lalitha Ammadu, Prasad, K.R.S., Krishna, P. Murali, Supraja, N., Shanmugan, S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9234593/
https://www.ncbi.nlm.nih.gov/pubmed/35770152
http://dx.doi.org/10.1016/j.heliyon.2022.e09726
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author Kolahalam, Lalitha Ammadu
Prasad, K.R.S.
Krishna, P. Murali
Supraja, N.
Shanmugan, S.
author_facet Kolahalam, Lalitha Ammadu
Prasad, K.R.S.
Krishna, P. Murali
Supraja, N.
Shanmugan, S.
author_sort Kolahalam, Lalitha Ammadu
collection PubMed
description The paper describes the synthesis and characterization of copper oxide nanoparticles (CuO NPs) using the mixture of plant rhizome extracts Ocimum sanctum and Saussurea lappa as a reducing agent. The prepared CuO nanoparticles are characterized and confirmed their formation based on data obtained from powder X-ray diffraction spectroscopy, Fourier Transmission Infrared, Ultraviolet-Visible spectra, Field Emission Scanning Electron Microscopy images, Energy Dispersive X-ray analysis and Dynamic light scattering techniques and data reveal that the average size of CuO Nps was 103.4 nm. The result of antibacterial and antifungal activities for concentrations 50, 100, and 170 ppm indicate that NPs may exhibit appreciable activity at higher (170 ppm) concentrations. The MTT cytotoxic assay studies of Chinese Hamster Ovary (CHO) cell lines showed a Half-maximal inhibitory concentration (IC(50)) value of 4.14 ​μg/mL.
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spelling pubmed-92345932022-06-28 The exploration of bio-inspired copper oxide nanoparticles: synthesis, characterization and in-vitro biological investigations Kolahalam, Lalitha Ammadu Prasad, K.R.S. Krishna, P. Murali Supraja, N. Shanmugan, S. Heliyon Research Article The paper describes the synthesis and characterization of copper oxide nanoparticles (CuO NPs) using the mixture of plant rhizome extracts Ocimum sanctum and Saussurea lappa as a reducing agent. The prepared CuO nanoparticles are characterized and confirmed their formation based on data obtained from powder X-ray diffraction spectroscopy, Fourier Transmission Infrared, Ultraviolet-Visible spectra, Field Emission Scanning Electron Microscopy images, Energy Dispersive X-ray analysis and Dynamic light scattering techniques and data reveal that the average size of CuO Nps was 103.4 nm. The result of antibacterial and antifungal activities for concentrations 50, 100, and 170 ppm indicate that NPs may exhibit appreciable activity at higher (170 ppm) concentrations. The MTT cytotoxic assay studies of Chinese Hamster Ovary (CHO) cell lines showed a Half-maximal inhibitory concentration (IC(50)) value of 4.14 ​μg/mL. Elsevier 2022-06-11 /pmc/articles/PMC9234593/ /pubmed/35770152 http://dx.doi.org/10.1016/j.heliyon.2022.e09726 Text en © 2022 The Author(s) https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Research Article
Kolahalam, Lalitha Ammadu
Prasad, K.R.S.
Krishna, P. Murali
Supraja, N.
Shanmugan, S.
The exploration of bio-inspired copper oxide nanoparticles: synthesis, characterization and in-vitro biological investigations
title The exploration of bio-inspired copper oxide nanoparticles: synthesis, characterization and in-vitro biological investigations
title_full The exploration of bio-inspired copper oxide nanoparticles: synthesis, characterization and in-vitro biological investigations
title_fullStr The exploration of bio-inspired copper oxide nanoparticles: synthesis, characterization and in-vitro biological investigations
title_full_unstemmed The exploration of bio-inspired copper oxide nanoparticles: synthesis, characterization and in-vitro biological investigations
title_short The exploration of bio-inspired copper oxide nanoparticles: synthesis, characterization and in-vitro biological investigations
title_sort exploration of bio-inspired copper oxide nanoparticles: synthesis, characterization and in-vitro biological investigations
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9234593/
https://www.ncbi.nlm.nih.gov/pubmed/35770152
http://dx.doi.org/10.1016/j.heliyon.2022.e09726
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