miR-146b suppresses LPS-induced M1 macrophage polarization via inhibiting the FGL2-activated NF-κB/MAPK signaling pathway in inflammatory bowel disease

OBJECTIVES: M1 macrophage polarization and phenotype in Inflammatory Bowel Disease (IBD) are common biological responses. METHOD: Herein, IBD mice models were constructed and macrophages were derived. RESULTS: It was discovered that microRNA-146b (miR-146b) was downregulated in IBD mice and Lipopoly...

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Detalles Bibliográficos
Autores principales: Pan, Yang, Wang, Dan, Liu, Fan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hospital das Clinicas da Faculdade de Medicina da Universidade de Sao Paulo 2022
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9234609/
https://www.ncbi.nlm.nih.gov/pubmed/35749999
http://dx.doi.org/10.1016/j.clinsp.2022.100069

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