Cargando…
Human Cytomegalovirus Induced Aberrant Expression of Non-coding RNAs
Human cytomegalovirus (HCMV) is a β-herpesvirus whose genome consists of double stranded linear DNA. HCMV genome can generate non-coding RNAs (ncRNAs) through transcription in its host cells. Besides that, HCMV infection also changes the ncRNAs expression profile of the host cells. ncRNAs play a key...
Autores principales: | , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2022
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9234646/ https://www.ncbi.nlm.nih.gov/pubmed/35770158 http://dx.doi.org/10.3389/fmicb.2022.918213 |
_version_ | 1784736126332829696 |
---|---|
author | Yu, Zhongjie Wang, Jing Nan, Fulong Shi, Wenyi Zhang, Xianjuan Jiang, Shasha Wang, Bin |
author_facet | Yu, Zhongjie Wang, Jing Nan, Fulong Shi, Wenyi Zhang, Xianjuan Jiang, Shasha Wang, Bin |
author_sort | Yu, Zhongjie |
collection | PubMed |
description | Human cytomegalovirus (HCMV) is a β-herpesvirus whose genome consists of double stranded linear DNA. HCMV genome can generate non-coding RNAs (ncRNAs) through transcription in its host cells. Besides that, HCMV infection also changes the ncRNAs expression profile of the host cells. ncRNAs play a key role in maintaining the normal physiological activity of cells, and the disorder of ncRNAs expression has numerous adverse effects on cells. However, until now, the relationship between ncRNAs and HCMV-induced adverse effects are not summarized in detail. This review aims to give a systematic summary of the role of HCMV infection in ncRNAs expression while providing insights into the molecular mechanism of unnormal cellular events caused by ncRNAs disorder. ncRNAs disorder induced by HCMV infection is highly associated with cell proliferation, apoptosis, tumorigenesis, and immune regulation, as well as the development of cardiovascular diseases, and the potential role of biomarker. We summarize the studies on HCMV associated ncRNAs disorder and suggest innovative strategies for eliminating the adverse effects caused by HCMV infection. |
format | Online Article Text |
id | pubmed-9234646 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-92346462022-06-28 Human Cytomegalovirus Induced Aberrant Expression of Non-coding RNAs Yu, Zhongjie Wang, Jing Nan, Fulong Shi, Wenyi Zhang, Xianjuan Jiang, Shasha Wang, Bin Front Microbiol Microbiology Human cytomegalovirus (HCMV) is a β-herpesvirus whose genome consists of double stranded linear DNA. HCMV genome can generate non-coding RNAs (ncRNAs) through transcription in its host cells. Besides that, HCMV infection also changes the ncRNAs expression profile of the host cells. ncRNAs play a key role in maintaining the normal physiological activity of cells, and the disorder of ncRNAs expression has numerous adverse effects on cells. However, until now, the relationship between ncRNAs and HCMV-induced adverse effects are not summarized in detail. This review aims to give a systematic summary of the role of HCMV infection in ncRNAs expression while providing insights into the molecular mechanism of unnormal cellular events caused by ncRNAs disorder. ncRNAs disorder induced by HCMV infection is highly associated with cell proliferation, apoptosis, tumorigenesis, and immune regulation, as well as the development of cardiovascular diseases, and the potential role of biomarker. We summarize the studies on HCMV associated ncRNAs disorder and suggest innovative strategies for eliminating the adverse effects caused by HCMV infection. Frontiers Media S.A. 2022-06-13 /pmc/articles/PMC9234646/ /pubmed/35770158 http://dx.doi.org/10.3389/fmicb.2022.918213 Text en Copyright © 2022 Yu, Wang, Nan, Shi, Zhang, Jiang and Wang. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Microbiology Yu, Zhongjie Wang, Jing Nan, Fulong Shi, Wenyi Zhang, Xianjuan Jiang, Shasha Wang, Bin Human Cytomegalovirus Induced Aberrant Expression of Non-coding RNAs |
title | Human Cytomegalovirus Induced Aberrant Expression of Non-coding RNAs |
title_full | Human Cytomegalovirus Induced Aberrant Expression of Non-coding RNAs |
title_fullStr | Human Cytomegalovirus Induced Aberrant Expression of Non-coding RNAs |
title_full_unstemmed | Human Cytomegalovirus Induced Aberrant Expression of Non-coding RNAs |
title_short | Human Cytomegalovirus Induced Aberrant Expression of Non-coding RNAs |
title_sort | human cytomegalovirus induced aberrant expression of non-coding rnas |
topic | Microbiology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9234646/ https://www.ncbi.nlm.nih.gov/pubmed/35770158 http://dx.doi.org/10.3389/fmicb.2022.918213 |
work_keys_str_mv | AT yuzhongjie humancytomegalovirusinducedaberrantexpressionofnoncodingrnas AT wangjing humancytomegalovirusinducedaberrantexpressionofnoncodingrnas AT nanfulong humancytomegalovirusinducedaberrantexpressionofnoncodingrnas AT shiwenyi humancytomegalovirusinducedaberrantexpressionofnoncodingrnas AT zhangxianjuan humancytomegalovirusinducedaberrantexpressionofnoncodingrnas AT jiangshasha humancytomegalovirusinducedaberrantexpressionofnoncodingrnas AT wangbin humancytomegalovirusinducedaberrantexpressionofnoncodingrnas |