Cargando…

Integrin subunit beta 8 contributes to lenvatinib resistance in HCC

Lenvatinib is a multikinase inhibitor approved as a first‐line therapy for advanced hepatocellular carcinoma (HCC). However, the development of drug resistance is common, and the underlying mechanisms governing this resistance are largely unknown. In this study, we established two lenvatinib‐resista...

Descripción completa

Detalles Bibliográficos
Autores principales:	Hou, Wei, Bridgeman, Bryan, Malnassy, Greg, Ding, Xianzhong, Cotler, Scott J., Dhanarajan, Asha, Qiu, Wei
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley and Sons Inc. 2022
Materias:	Original Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9234648/ https://www.ncbi.nlm.nih.gov/pubmed/35238496 http://dx.doi.org/10.1002/hep4.1928

Ejemplares similares

Inhibition of Abelson Tyrosine-Protein Kinase 2 Suppresses the Development of Alcohol-Associated Liver Disease by Decreasing PPARgamma Expression
por: Malnassy, Greg, et al.
Publicado: (2023)

Proteolytic processing of endogenous and recombinant beta 4 integrin subunit
Publicado: (1992)

Cytoplasmic and transmembrane domains of integrin beta 1 and beta 3 subunits are functionally interchangeable
Publicado: (1991)

Inhibition of insulin‐like growth factor 1 receptor enhances the efficacy of sorafenib in inhibiting hepatocellular carcinoma cell growth and survival
por: Wang, Fang, et al.
Publicado: (2018)

The Epigenetic Regulation of Microenvironment in Hepatocellular Carcinoma
por: Wang, Fang, et al.
Publicado: (2021)

Lenvatinib enhances antitumor immunity by promoting the infiltration of TCF1 (+) CD8 (+) T cells in HCC via blocking VEGFR2
por: Mei, Zhibin, et al.
Publicado: (2023)

Impact of modified albumin–bilirubin grade on survival in patients with HCC who received lenvatinib
por: Tada, Toshifumi, et al.
Publicado: (2021)

Regulation of the VLA integrin-ligand interactions through the beta 1 subunit
Publicado: (1992)

An interaction between alpha-actinin and the beta 1 integrin subunit in vitro
Publicado: (1990)

Structure/function analysis of the integrin beta 1 subunit by epitope mapping
Publicado: (1993)

Efficacy and safety of TACE combined with lenvatinib and PD‐1 inhibitors for unresectable recurrent HCC: A multicenter, retrospective study
por: Wang, Wei‐Jun, et al.
Publicado: (2023)

Integrin Subunit beta 8 (ITGB8) Upregulation Is an Independent Predictor of Unfavorable Survival of High-Grade Serous Ovarian Carcinoma Patients
por: He, Jing, et al.
Publicado: (2018)

In vivo analyses of integrin beta 1 subunit function in fibronectin matrix assembly
Publicado: (1990)

ITGB (Integrin subunit beta) 3 mutation involved in pulmonary hemorrhage and osteopetrosis
por: Sendon, Carlos, et al.
Publicado: (2019)

Localization of Integrin Beta-4 Subunit at Soft Tissue–Titanium or Zirconia Interface
por: Ayukawa, Yasunori, et al.
Publicado: (2020)

Inactivation of the integrin beta 6 subunit gene reveals a role of epithelial integrins in regulating inflammation in the lung and skin
Publicado: (1996)

On the contributing role of the transmembrane domain for subunit-specific sensitivity of integrin activation
por: Pagani, Giulia, et al.
Publicado: (2018)

Modified Hepatic Arterial Infusion Chemotherapy Combined with Lenvatinib and Camrelizumab for Advanced HCC: Two Case Reports
por: Tian, Yuan, et al.
Publicado: (2023)

Beta 3-endonexin, a novel polypeptide that interacts specifically with the cytoplasmic tail of the integrin beta 3 subunit
Publicado: (1995)

SREBP2 inhibitor betulin sensitizes hepatocellular carcinoma to lenvatinib by inhibiting the mTOR/IL-1β pathway: SREBP2 Inhibitor sensitizes HCC to lenvatinib
por: Fan, Minghao, et al.
Publicado: (2023)

Requirement of the integrin beta 3 subunit for carcinoma cell spreading or migration on vitronectin and fibrinogen
Publicado: (1992)

Expression and functional analysis of a cytoplasmic domain variant of the beta 1 integrin subunit
Publicado: (1993)

TM4SF1 upregulates MYH9 to activate the NOTCH pathway to promote cancer stemness and lenvatinib resistance in HCC
por: Yang, Si-bo, et al.
Publicado: (2023)

Activation of the alpha 4 beta 1 integrin through the beta 1 subunit induces recognition of the RGDS sequence in fibronectin
Publicado: (1994)

Cost-effectiveness analysis of lenvatinib treatment for patients with unresectable hepatocellular carcinoma (uHCC) compared with sorafenib in Japan
por: Kobayashi, Masahiro, et al.
Publicado: (2019)

A Real-World Comparative Analysis of Lenvatinib and Sorafenib as a Salvage Therapy for Transarterial Treatments in Unresectable HCC
por: Lee, Jaejun, et al.
Publicado: (2020)

IRF2 regulates cellular survival and Lenvatinib-sensitivity of hepatocellular carcinoma (HCC) through regulating β-catenin
por: Guo, Yarong, et al.
Publicado: (2021)

Lenvatinib in combination with transarterial chemoembolization for treatment of unresectable hepatocellular carcinoma (uHCC): a retrospective controlled study
por: Fu, Zhigang, et al.
Publicado: (2021)

Does first‐line treatment have prognostic impact for unresectable HCC?—Atezolizumab plus bevacizumab versus lenvatinib
por: Hiraoka, Atsushi, et al.
Publicado: (2022)

C-reactive protein can predict dose intensity, time to treatment failure and overall survival in HCC treated with lenvatinib
por: Hayashi, Tsuguru, et al.
Publicado: (2020)

Distinct functions of integrin alpha and beta subunit cytoplasmic domains in cell spreading and formation of focal adhesions
Publicado: (1993)

Antibodies to the conserved cytoplasmic domain of the integrin beta 1 subunit react with proteins in vertebrates, invertebrates, and fungi
Publicado: (1988)

MicroRNA-183-5p Inhibits Aggressiveness of Cervical Cancer Cells by Targeting Integrin Subunit Beta 1 (ITGB1)
por: Zhang, Wei, et al.
Publicado: (2018)

Requirement of the NPXY motif in the integrin beta 3 subunit cytoplasmic tail for melanoma cell migration in vitro and in vivo
Publicado: (1995)

Regulation of alpha 6 beta 1 integrin laminin receptor function by the cytoplasmic domain of the alpha 6 subunit
Publicado: (1993)

Partial Sperm beta1 Integrin Subunit Deletion Proves Its Involvement in Mouse Gamete Adhesion/Fusion
por: Barraud-Lange, Virginie, et al.
Publicado: (2020)

A point mutation of integrin beta 1 subunit blocks binding of alpha 5 beta 1 to fibronectin and invasin but not recruitment to adhesion plaques
Publicado: (1992)

Lenvatinib, toripalimab, plus hepatic arterial infusion chemotherapy versus lenvatinib alone for advanced hepatocellular carcinoma
por: He, Min-Ke, et al.
Publicado: (2021)

Epitopes in α8β1 and other RGD-binding integrins delineate classes of integrin-blocking antibodies and major binding loops in α subunits
por: Nishimichi, Norihisa, et al.
Publicado: (2015)

Lenvatinib recruits cytotoxic GZMK+CD8 T cells in hepatocellular carcinoma
por: Yamada, Tomoharu, et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_7sp75qhsv4ec4pccslbtd8428d