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Findings of in vitro Analyses of Basophil Functions May Help Us Better Understand Drug Desensitization
Drug hypersensitivity can be an important problem during pharmacological management of various diseases. Patients diagnosed as having a drug allergy usually need to avoid the offending drug, either temporarily or for life. Another way of overcoming a drug allergy is to establish desensitization usin...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9234864/ https://www.ncbi.nlm.nih.gov/pubmed/35769573 http://dx.doi.org/10.3389/falgy.2022.874772 |
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author | Yamaguchi, Masao Komiya, Akiko Suzukawa, Maho Koketsu, Rikiya Shiragami, Risa Iikura, Motoyasu Nagase, Hiroyuki |
author_facet | Yamaguchi, Masao Komiya, Akiko Suzukawa, Maho Koketsu, Rikiya Shiragami, Risa Iikura, Motoyasu Nagase, Hiroyuki |
author_sort | Yamaguchi, Masao |
collection | PubMed |
description | Drug hypersensitivity can be an important problem during pharmacological management of various diseases. Patients diagnosed as having a drug allergy usually need to avoid the offending drug, either temporarily or for life. Another way of overcoming a drug allergy is to establish desensitization using the allergen drug itself. We previously investigated in vitro desensitization of human basophils using a subthreshold dose of an IgE-crosslinking reagent. We found that basophil desensitization occurred in a dose-dependent manner over a period of one to several hours. We think that inducible basophil desensitization occurring without histamine release may explain, at least in part, the clinical features of drug desensitization in type 1 drug allergy. |
format | Online Article Text |
id | pubmed-9234864 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-92348642022-06-28 Findings of in vitro Analyses of Basophil Functions May Help Us Better Understand Drug Desensitization Yamaguchi, Masao Komiya, Akiko Suzukawa, Maho Koketsu, Rikiya Shiragami, Risa Iikura, Motoyasu Nagase, Hiroyuki Front Allergy Allergy Drug hypersensitivity can be an important problem during pharmacological management of various diseases. Patients diagnosed as having a drug allergy usually need to avoid the offending drug, either temporarily or for life. Another way of overcoming a drug allergy is to establish desensitization using the allergen drug itself. We previously investigated in vitro desensitization of human basophils using a subthreshold dose of an IgE-crosslinking reagent. We found that basophil desensitization occurred in a dose-dependent manner over a period of one to several hours. We think that inducible basophil desensitization occurring without histamine release may explain, at least in part, the clinical features of drug desensitization in type 1 drug allergy. Frontiers Media S.A. 2022-03-30 /pmc/articles/PMC9234864/ /pubmed/35769573 http://dx.doi.org/10.3389/falgy.2022.874772 Text en Copyright © 2022 Yamaguchi, Komiya, Suzukawa, Koketsu, Shiragami, Iikura and Nagase. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Allergy Yamaguchi, Masao Komiya, Akiko Suzukawa, Maho Koketsu, Rikiya Shiragami, Risa Iikura, Motoyasu Nagase, Hiroyuki Findings of in vitro Analyses of Basophil Functions May Help Us Better Understand Drug Desensitization |
title | Findings of in vitro Analyses of Basophil Functions May Help Us Better Understand Drug Desensitization |
title_full | Findings of in vitro Analyses of Basophil Functions May Help Us Better Understand Drug Desensitization |
title_fullStr | Findings of in vitro Analyses of Basophil Functions May Help Us Better Understand Drug Desensitization |
title_full_unstemmed | Findings of in vitro Analyses of Basophil Functions May Help Us Better Understand Drug Desensitization |
title_short | Findings of in vitro Analyses of Basophil Functions May Help Us Better Understand Drug Desensitization |
title_sort | findings of in vitro analyses of basophil functions may help us better understand drug desensitization |
topic | Allergy |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9234864/ https://www.ncbi.nlm.nih.gov/pubmed/35769573 http://dx.doi.org/10.3389/falgy.2022.874772 |
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