GM-CSF disruption in CART cells modulates T cell activation and enhances CART cell anti-tumor activity

Inhibitory myeloid cells and their cytokines play critical roles in limiting chimeric antigen receptor T (CART) cell therapy by contributing to the development of toxicities and resistance following infusion. We have previously shown that neutralization of granulocyte-macrophage colony-stimulating f...

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Detalles Bibliográficos
Autores principales: Cox, Michelle J., Roman, Claudia Manriquez, Tapper, Erin E., Siegler, Elizabeth L., Chappell, Dale, Durrant, Cameron, Ahmed, Omar, Sinha, Sutapa, Mwangi, Raphael, Scott, Nancy S., Hefazi, Mehrdad, Schick, Kendall J., Horvei, Paulina, Ruff, Michael W., Can, Ismail, Adada, Mohamad, Bezerra, Evandro, Fonkoua, Lionel Aurelien Kankeu, Parikh, Sameer A., Kay, Neil E., Sakemura, Reona, Kenderian, Saad S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9234947/
https://www.ncbi.nlm.nih.gov/pubmed/35440691
http://dx.doi.org/10.1038/s41375-022-01572-7

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