Endothelial cell derived angiocrine support of acute myeloid leukemia targeted by receptor tyrosine kinase inhibition

In acute myeloid leukemia (AML), refractory disease is a major challenge and the leukemia microenvironment may harbor refractory disease. Human AML cell lines KG-1 and HL-60 expressed receptors also found on endothelial cells (ECs) such as VEGFRs, PDGFRs, and cKit. When human AML cells were co-cultu...

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Detalles Bibliográficos
Autores principales: Drusbosky, Leylah, Gars, Eric, Trujillo, Angelica, McGee, Christie, Meacham, Amy, Wise, Elizabeth, Scott, Edward W., Cogle, Christopher R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9234949/
https://www.ncbi.nlm.nih.gov/pubmed/26189107
http://dx.doi.org/10.1016/j.leukres.2015.05.015

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