Transcriptional Reprogramming Differentiates Active from Inactive ESR1 Fusions in Endocrine Therapy-Refractory Metastatic Breast Cancer

Genomic analysis has recently identified multiple ESR1 gene translocations in estrogen receptor alpha–positive (ERα(+)) metastatic breast cancer (MBC) that encode chimeric proteins whereby the ESR1 ligand binding domain (LBD) is replaced by C-terminal sequences from many different gene partners. Her...

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Detalles Bibliográficos
Autores principales: Gou, Xuxu, Anurag, Meenakshi, Lei, Jonathan T., Kim, Beom-Jun, Singh, Purba, Seker, Sinem, Fandino, Diana, Han, Airi, Rehman, Saif, Hu, Jianhong, Korchina, Viktoriya, Doddapaneni, Harshavardhan, Dobrolecki, Lacey E., Mitsiades, Nicholas, Lewis, Michael T., Welm, Alana L., Li, Shunqiang, Lee, Adrian V., Robinson, Dan R., Foulds, Charles E., Ellis, Matthew J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for Cancer Research 2021
Materias:
Translational Science
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9234971/
https://www.ncbi.nlm.nih.gov/pubmed/34711608
http://dx.doi.org/10.1158/0008-5472.CAN-21-1256

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