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Significant Differences in the Bacterial Microbiome of the Pharynx and Skin in Patients with Psoriasis Compared with Healthy Controls

Studies have shown differences in the skin and gut bacterial microbiomes in patients with psoriasis, but the pharyngeal microbiome has not been studied previously. The aim of this study was to investigate differences in the bacterial microbiome of the pharynx and skin of patients with psoriasis comp...

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Autores principales: ASSARSSON, Malin, SÖDERMAN, Jan, DIENUS, Olaf, SEIFERT, Oliver
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Society for Publication of Acta Dermato-Venereologica 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9234991/
https://www.ncbi.nlm.nih.gov/pubmed/32852562
http://dx.doi.org/10.2340/00015555-3619
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author ASSARSSON, Malin
SÖDERMAN, Jan
DIENUS, Olaf
SEIFERT, Oliver
author_facet ASSARSSON, Malin
SÖDERMAN, Jan
DIENUS, Olaf
SEIFERT, Oliver
author_sort ASSARSSON, Malin
collection PubMed
description Studies have shown differences in the skin and gut bacterial microbiomes in patients with psoriasis, but the pharyngeal microbiome has not been studied previously. The aim of this study was to investigate differences in the bacterial microbiome of the pharynx and skin of patients with psoriasis compared with healthy controls. Swabs were taken from the pharynx and elbow skin of 39 patients with psoriasis and 70 controls. Microbiomes were characterized by sequencing 16S rRNA genes on the Illumina MiSeq platform. Significant differences were found in alpha and beta diversity in the skin, but not in the pharynx. Significant differences were also found between several phyla and genera in both skin and pharynx. The severity of psoriasis did not correlate with any genera in the pharynx, but with Capnocytophaga, Leptotrichia, Abiotrophia and Tannerella in the skin. The composition of the pharyngeal and skin microbiome may be of importance in the pathogenesis of psoriasis.
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spelling pubmed-92349912022-10-20 Significant Differences in the Bacterial Microbiome of the Pharynx and Skin in Patients with Psoriasis Compared with Healthy Controls ASSARSSON, Malin SÖDERMAN, Jan DIENUS, Olaf SEIFERT, Oliver Acta Derm Venereol Clinical Report Studies have shown differences in the skin and gut bacterial microbiomes in patients with psoriasis, but the pharyngeal microbiome has not been studied previously. The aim of this study was to investigate differences in the bacterial microbiome of the pharynx and skin of patients with psoriasis compared with healthy controls. Swabs were taken from the pharynx and elbow skin of 39 patients with psoriasis and 70 controls. Microbiomes were characterized by sequencing 16S rRNA genes on the Illumina MiSeq platform. Significant differences were found in alpha and beta diversity in the skin, but not in the pharynx. Significant differences were also found between several phyla and genera in both skin and pharynx. The severity of psoriasis did not correlate with any genera in the pharynx, but with Capnocytophaga, Leptotrichia, Abiotrophia and Tannerella in the skin. The composition of the pharyngeal and skin microbiome may be of importance in the pathogenesis of psoriasis. Society for Publication of Acta Dermato-Venereologica 2020-09-30 /pmc/articles/PMC9234991/ /pubmed/32852562 http://dx.doi.org/10.2340/00015555-3619 Text en © 2020 Acta Dermato-Venereologica https://creativecommons.org/licenses/by-nc/4.0/This is an open access article under the CC BY-NC license
spellingShingle Clinical Report
ASSARSSON, Malin
SÖDERMAN, Jan
DIENUS, Olaf
SEIFERT, Oliver
Significant Differences in the Bacterial Microbiome of the Pharynx and Skin in Patients with Psoriasis Compared with Healthy Controls
title Significant Differences in the Bacterial Microbiome of the Pharynx and Skin in Patients with Psoriasis Compared with Healthy Controls
title_full Significant Differences in the Bacterial Microbiome of the Pharynx and Skin in Patients with Psoriasis Compared with Healthy Controls
title_fullStr Significant Differences in the Bacterial Microbiome of the Pharynx and Skin in Patients with Psoriasis Compared with Healthy Controls
title_full_unstemmed Significant Differences in the Bacterial Microbiome of the Pharynx and Skin in Patients with Psoriasis Compared with Healthy Controls
title_short Significant Differences in the Bacterial Microbiome of the Pharynx and Skin in Patients with Psoriasis Compared with Healthy Controls
title_sort significant differences in the bacterial microbiome of the pharynx and skin in patients with psoriasis compared with healthy controls
topic Clinical Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9234991/
https://www.ncbi.nlm.nih.gov/pubmed/32852562
http://dx.doi.org/10.2340/00015555-3619
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