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Inhibition of autophagy by chloroquine prevents resistance to PI3K/AKT inhibitors and potentiates their antitumor effect in combination with paclitaxel in triple negative breast cancer models

BACKGROUND: Triple negative breast cancer (TNBC) is an aggressive disease characterized by high risk of relapse and development of resistance to different chemotherapy agents. Several targeted therapies have been investigated in TNBC with modest results in clinical trials. Among these, PI3K/AKT inhi...

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Detalles Bibliográficos
Autores principales:	Cocco, Stefania, Leone, Alessandra, Roca, Maria Serena, Lombardi, Rita, Piezzo, Michela, Caputo, Roberta, Ciardiello, Chiara, Costantini, Susan, Bruzzese, Francesca, Sisalli, Maria José, Budillon, Alfredo, De Laurentiis, Michelino
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2022
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9235112/ https://www.ncbi.nlm.nih.gov/pubmed/35761360 http://dx.doi.org/10.1186/s12967-022-03462-z

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