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Tumor-suppressive MEG3 induces microRNA-493-5p expression to reduce arabinocytosine chemoresistance of acute myeloid leukemia cells by downregulating the METTL3/MYC axis

BACKGROUND: Chemoresistance serves as a huge obstacle for acute myeloid leukemia (AML) patients. To counteract the chemoresistance in AML cells, we discussed the role of maternally expressed gene 3 (MEG3) in arabinocytosine (AraC) chemoresistance in AML cells. METHODS: MEG3, microRNA (miR)-493-5p, m...

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Detalles Bibliográficos
Autores principales:	Wang, Airong, Chen, Yufei, Shi, Luyao, Li, Mengya, Li, Lingling, Wang, Shujuan, Wang, Chong
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2022
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9235226/ https://www.ncbi.nlm.nih.gov/pubmed/35761379 http://dx.doi.org/10.1186/s12967-022-03456-x

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