Clonidine Overdose as an Unusual Cause of Heart Failure

Clonidine is used as an antihypertensive medication due to its effect on decreasing peripheral vascular resistance and therefore lowering blood pressure. Alpha antagonism in the medulla and the posterior hypothalamus causing a reduction in sympathetic activation allows for clonidine to be used as an...

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Autores principales: Bhullar, Jagdeep, Patel, Arti, Chitithoti, Jaagruthi, Venter, Frederick, Win, Theingi, Joolhar, Fowrooz
Formato: Online Artículo Texto
Lenguaje:English
Publicado: SAGE Publications 2022
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9235301/
https://www.ncbi.nlm.nih.gov/pubmed/35748424
http://dx.doi.org/10.1177/23247096221106856
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author Bhullar, Jagdeep
Patel, Arti
Chitithoti, Jaagruthi
Venter, Frederick
Win, Theingi
Joolhar, Fowrooz
author_facet Bhullar, Jagdeep
Patel, Arti
Chitithoti, Jaagruthi
Venter, Frederick
Win, Theingi
Joolhar, Fowrooz
author_sort Bhullar, Jagdeep
collection PubMed
description Clonidine is used as an antihypertensive medication due to its effect on decreasing peripheral vascular resistance and therefore lowering blood pressure. Alpha antagonism in the medulla and the posterior hypothalamus causing a reduction in sympathetic activation allows for clonidine to be used as an effective off-label treatment for attention-deficit/hyperactivity disorder (ADHD). This is a case of a 28-year-old female with hypertension, ADHD, and depression who developed acute heart failure with significant troponemia after ingesting 30 pills of clonidine. We illustrate the possible rare diagnosis of systolic heart failure and coronary vasospasm secondary to clonidine overdose.
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spelling pubmed-92353012022-06-28 Clonidine Overdose as an Unusual Cause of Heart Failure Bhullar, Jagdeep Patel, Arti Chitithoti, Jaagruthi Venter, Frederick Win, Theingi Joolhar, Fowrooz J Investig Med High Impact Case Rep Case Report Clonidine is used as an antihypertensive medication due to its effect on decreasing peripheral vascular resistance and therefore lowering blood pressure. Alpha antagonism in the medulla and the posterior hypothalamus causing a reduction in sympathetic activation allows for clonidine to be used as an effective off-label treatment for attention-deficit/hyperactivity disorder (ADHD). This is a case of a 28-year-old female with hypertension, ADHD, and depression who developed acute heart failure with significant troponemia after ingesting 30 pills of clonidine. We illustrate the possible rare diagnosis of systolic heart failure and coronary vasospasm secondary to clonidine overdose. SAGE Publications 2022-06-24 /pmc/articles/PMC9235301/ /pubmed/35748424 http://dx.doi.org/10.1177/23247096221106856 Text en © 2022 American Federation for Medical Research https://creativecommons.org/licenses/by/4.0/This article is distributed under the terms of the Creative Commons Attribution 4.0 License (https://creativecommons.org/licenses/by/4.0/) which permits any use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access page (https://us.sagepub.com/en-us/nam/open-access-at-sage).
spellingShingle Case Report
Bhullar, Jagdeep
Patel, Arti
Chitithoti, Jaagruthi
Venter, Frederick
Win, Theingi
Joolhar, Fowrooz
Clonidine Overdose as an Unusual Cause of Heart Failure
title Clonidine Overdose as an Unusual Cause of Heart Failure
title_full Clonidine Overdose as an Unusual Cause of Heart Failure
title_fullStr Clonidine Overdose as an Unusual Cause of Heart Failure
title_full_unstemmed Clonidine Overdose as an Unusual Cause of Heart Failure
title_short Clonidine Overdose as an Unusual Cause of Heart Failure
title_sort clonidine overdose as an unusual cause of heart failure
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9235301/
https://www.ncbi.nlm.nih.gov/pubmed/35748424
http://dx.doi.org/10.1177/23247096221106856
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