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Posttransplantation tuberculosis management in terms of immunosuppressant cost: a case report in Myanmar

Drug interactions between anti-tuberculosis and immunosuppressive medications after renal transplantation are a common problem in Myanmar. The efficacy of both types of drugs can be reduced during the treatment period, which can lead to graft failure and flare-ups of infection. Drug adjustments, wit...

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Detalles Bibliográficos
Autores principales: Lwin, Phyo Wai, Htun, Yi Yi, Myint, Aung Kyaw, Swe, Htar Kyi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Korean Society for Transplantation 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9235332/
https://www.ncbi.nlm.nih.gov/pubmed/35769623
http://dx.doi.org/10.4285/kjt.20.0041
Descripción
Sumario:Drug interactions between anti-tuberculosis and immunosuppressive medications after renal transplantation are a common problem in Myanmar. The efficacy of both types of drugs can be reduced during the treatment period, which can lead to graft failure and flare-ups of infection. Drug adjustments, with frequent monitoring and close follow-up, are crucial in this period. Ketoconazole decreases tacrolimus metabolism by inhibiting cytochrome P450-3A5 enzymes and P-glycoprotein. It is cost effective and has been frequently used to reduce the dose and cost of tacrolimus. Here, we report the case of a 56-year-old male renal transplant recipient with anti-tuberculosis medications.