Regulatory Architecture of the RCA Gene Cluster Captures an Intragenic TAD Boundary, CTCF-Mediated Chromatin Looping and a Long-Range Intergenic Enhancer

The Regulators of Complement Activation (RCA) gene cluster comprises several tandemly arranged genes with shared functions within the immune system. RCA members, such as complement receptor 2 (CR2), are well-established susceptibility genes in complex autoimmune diseases. Altered expression of RCA g...

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Detalles Bibliográficos
Autores principales: Cheng, Jessica, Clayton, Joshua S., Acemel, Rafael D., Zheng, Ye, Taylor, Rhonda L., Keleş, Sündüz, Franke, Martin, Boackle, Susan A., Harley, John B., Quail, Elizabeth, Gómez-Skarmeta, José Luis, Ulgiati, Daniela
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9235356/
https://www.ncbi.nlm.nih.gov/pubmed/35769482
http://dx.doi.org/10.3389/fimmu.2022.901747

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