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Potential Benefits of Selenium Supplementation in Patients with Kidney Disease

Trace element deficiency is common among patients with end-stage renal disease (ESRD); the reason is that since these patients undergo dialysis, they lose these elements more than healthy people, and also the use of trace elements is restricted due to loss of appetite. Selenium (Se) is a trace eleme...

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Autores principales: Badri, Shirinsadat, Vahdat, Sahar, Pourfarzam, Morteza, Assarzadeh, Samaneh, Seirafian, Shiva, Ataei, Sara
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Wolters Kluwer - Medknow 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9235365/
https://www.ncbi.nlm.nih.gov/pubmed/35769838
http://dx.doi.org/10.4103/jrpp.jrpp_3_22
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author Badri, Shirinsadat
Vahdat, Sahar
Pourfarzam, Morteza
Assarzadeh, Samaneh
Seirafian, Shiva
Ataei, Sara
author_facet Badri, Shirinsadat
Vahdat, Sahar
Pourfarzam, Morteza
Assarzadeh, Samaneh
Seirafian, Shiva
Ataei, Sara
author_sort Badri, Shirinsadat
collection PubMed
description Trace element deficiency is common among patients with end-stage renal disease (ESRD); the reason is that since these patients undergo dialysis, they lose these elements more than healthy people, and also the use of trace elements is restricted due to loss of appetite. Selenium (Se) is a trace element that is essential for the oxidative stress defense system. Se deficiency leads to some complications similar to those often seen in ESRD patients, such as all-cause mortality due to cardiovascular diseases, bone loss, uric acid elevation, and anemia. This article aims to review the evidence on consequences of Se deficiency in ESRD patients, as well as effects of Se supplementation in hemodialysis patients. Multiple databases were searched to summarize the available evidence on selenium's role in kidney diseases. Since the complications of ESRD and those of Se deficiency are mostly similar, this triggers the idea that Se deficiency may be considered as a cause of these problems, but it needs to be more assessed that Se deficiency is a single factor or there are other factors participated in. Also the role of Se supplementation on resolving the mentioned complications, needs to be more studied through welldesigned clinical studies.
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spelling pubmed-92353652022-06-28 Potential Benefits of Selenium Supplementation in Patients with Kidney Disease Badri, Shirinsadat Vahdat, Sahar Pourfarzam, Morteza Assarzadeh, Samaneh Seirafian, Shiva Ataei, Sara J Res Pharm Pract Review Article Trace element deficiency is common among patients with end-stage renal disease (ESRD); the reason is that since these patients undergo dialysis, they lose these elements more than healthy people, and also the use of trace elements is restricted due to loss of appetite. Selenium (Se) is a trace element that is essential for the oxidative stress defense system. Se deficiency leads to some complications similar to those often seen in ESRD patients, such as all-cause mortality due to cardiovascular diseases, bone loss, uric acid elevation, and anemia. This article aims to review the evidence on consequences of Se deficiency in ESRD patients, as well as effects of Se supplementation in hemodialysis patients. Multiple databases were searched to summarize the available evidence on selenium's role in kidney diseases. Since the complications of ESRD and those of Se deficiency are mostly similar, this triggers the idea that Se deficiency may be considered as a cause of these problems, but it needs to be more assessed that Se deficiency is a single factor or there are other factors participated in. Also the role of Se supplementation on resolving the mentioned complications, needs to be more studied through welldesigned clinical studies. Wolters Kluwer - Medknow 2022-05-25 /pmc/articles/PMC9235365/ /pubmed/35769838 http://dx.doi.org/10.4103/jrpp.jrpp_3_22 Text en Copyright: © 2022 Journal of Research in Pharmacy Practice https://creativecommons.org/licenses/by-nc-sa/4.0/This is an open access journal, and articles are distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as appropriate credit is given and the new creations are licensed under the identical terms.
spellingShingle Review Article
Badri, Shirinsadat
Vahdat, Sahar
Pourfarzam, Morteza
Assarzadeh, Samaneh
Seirafian, Shiva
Ataei, Sara
Potential Benefits of Selenium Supplementation in Patients with Kidney Disease
title Potential Benefits of Selenium Supplementation in Patients with Kidney Disease
title_full Potential Benefits of Selenium Supplementation in Patients with Kidney Disease
title_fullStr Potential Benefits of Selenium Supplementation in Patients with Kidney Disease
title_full_unstemmed Potential Benefits of Selenium Supplementation in Patients with Kidney Disease
title_short Potential Benefits of Selenium Supplementation in Patients with Kidney Disease
title_sort potential benefits of selenium supplementation in patients with kidney disease
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9235365/
https://www.ncbi.nlm.nih.gov/pubmed/35769838
http://dx.doi.org/10.4103/jrpp.jrpp_3_22
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