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Association Between Sleep Duration and Parkinson’s Disease Varied Across Related Orphan Receptor A rs2028122 Genotypes

BACKGROUND: The purpose of the study was to examine the association of long and short sleep duration with risk of Parkinson’s disease (PD) across RORA rs2028122 genotypes. METHODS: In the present prospective study with a large sized UK Biobank cohort, we performed multivariate logistic regression an...

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Autores principales: Shao, Yuan, Dai, Xi-jian, Wang, Jian, Wang, Yongjun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9235404/
https://www.ncbi.nlm.nih.gov/pubmed/35769699
http://dx.doi.org/10.3389/fnins.2022.902895
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author Shao, Yuan
Dai, Xi-jian
Wang, Jian
Wang, Yongjun
author_facet Shao, Yuan
Dai, Xi-jian
Wang, Jian
Wang, Yongjun
author_sort Shao, Yuan
collection PubMed
description BACKGROUND: The purpose of the study was to examine the association of long and short sleep duration with risk of Parkinson’s disease (PD) across RORA rs2028122 genotypes. METHODS: In the present prospective study with a large sized UK Biobank cohort, we performed multivariate logistic regression analyses, generalized additive model, interaction terms, stratification analysis, and mediation analysis to evaluate the association of long and short sleep duration with risk of PD across RORA rs2028122 genotypes. RESULTS: The GG genotype [1.16 (1.01, 1.33)], a short sleep duration [1.23 (1.10, 1.37)], and a long sleep duration [1.19 (1.03, 1.37)] were identified as the independent risk factors for PD. Sleep duration exhibited a curvilinear U-shaped correlation with the risk of PD; first, the risk of PD gradually decreased as the length of sleep increase, but then, the risk began to increase as the length of sleep increase. Among habitual long sleepers, AG carriers had a higher risk of PD compared with AA carriers [1.67 (1.09, 2.55)]. Among AG carriers, both habitual short [1.28 (1.09, 1.50)] and long [1.38 (1.13, 1.69)] sleepers increased the risk of PD compared with habitual normal sleepers. Among GG carriers, habitual short sleepers have a higher risk of PD [1.26 (1.06, 1.50)] compared with habitual normal sleepers. A mediation model suggested that the rs2028122 genotype partially mediated the causal pathway of sleep duration leading to the development of PD on a positive effect. CONCLUSION: Our study demonstrated that the association between sleep duration and PD risk varied across different RORA rs2028122 genotypes. Our findings could help individuals to identify their potential risk profile and take timely actions to prevent the PD.
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spelling pubmed-92354042022-06-28 Association Between Sleep Duration and Parkinson’s Disease Varied Across Related Orphan Receptor A rs2028122 Genotypes Shao, Yuan Dai, Xi-jian Wang, Jian Wang, Yongjun Front Neurosci Neuroscience BACKGROUND: The purpose of the study was to examine the association of long and short sleep duration with risk of Parkinson’s disease (PD) across RORA rs2028122 genotypes. METHODS: In the present prospective study with a large sized UK Biobank cohort, we performed multivariate logistic regression analyses, generalized additive model, interaction terms, stratification analysis, and mediation analysis to evaluate the association of long and short sleep duration with risk of PD across RORA rs2028122 genotypes. RESULTS: The GG genotype [1.16 (1.01, 1.33)], a short sleep duration [1.23 (1.10, 1.37)], and a long sleep duration [1.19 (1.03, 1.37)] were identified as the independent risk factors for PD. Sleep duration exhibited a curvilinear U-shaped correlation with the risk of PD; first, the risk of PD gradually decreased as the length of sleep increase, but then, the risk began to increase as the length of sleep increase. Among habitual long sleepers, AG carriers had a higher risk of PD compared with AA carriers [1.67 (1.09, 2.55)]. Among AG carriers, both habitual short [1.28 (1.09, 1.50)] and long [1.38 (1.13, 1.69)] sleepers increased the risk of PD compared with habitual normal sleepers. Among GG carriers, habitual short sleepers have a higher risk of PD [1.26 (1.06, 1.50)] compared with habitual normal sleepers. A mediation model suggested that the rs2028122 genotype partially mediated the causal pathway of sleep duration leading to the development of PD on a positive effect. CONCLUSION: Our study demonstrated that the association between sleep duration and PD risk varied across different RORA rs2028122 genotypes. Our findings could help individuals to identify their potential risk profile and take timely actions to prevent the PD. Frontiers Media S.A. 2022-06-13 /pmc/articles/PMC9235404/ /pubmed/35769699 http://dx.doi.org/10.3389/fnins.2022.902895 Text en Copyright © 2022 Shao, Dai, Wang and Wang. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Neuroscience
Shao, Yuan
Dai, Xi-jian
Wang, Jian
Wang, Yongjun
Association Between Sleep Duration and Parkinson’s Disease Varied Across Related Orphan Receptor A rs2028122 Genotypes
title Association Between Sleep Duration and Parkinson’s Disease Varied Across Related Orphan Receptor A rs2028122 Genotypes
title_full Association Between Sleep Duration and Parkinson’s Disease Varied Across Related Orphan Receptor A rs2028122 Genotypes
title_fullStr Association Between Sleep Duration and Parkinson’s Disease Varied Across Related Orphan Receptor A rs2028122 Genotypes
title_full_unstemmed Association Between Sleep Duration and Parkinson’s Disease Varied Across Related Orphan Receptor A rs2028122 Genotypes
title_short Association Between Sleep Duration and Parkinson’s Disease Varied Across Related Orphan Receptor A rs2028122 Genotypes
title_sort association between sleep duration and parkinson’s disease varied across related orphan receptor a rs2028122 genotypes
topic Neuroscience
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9235404/
https://www.ncbi.nlm.nih.gov/pubmed/35769699
http://dx.doi.org/10.3389/fnins.2022.902895
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