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The Relationship Between Suboptimal Social Networks and Postoperative Delirium: The PNDABLE Study
BACKGROUND: Although it has been proven that social networks are related to cognition, studies are conducted to characterize the correlation between social networks and postoperative delirium (POD). OBJECTIVE: We investigated whether suboptimal social networks are a risk factor for POD, and to verif...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9235411/ https://www.ncbi.nlm.nih.gov/pubmed/35769605 http://dx.doi.org/10.3389/fnagi.2022.851368 |
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author | Tang, Xinhui Yv, Hui Wang, Fei Wang, Jiahan Liu, Siyv Wu, Xiaoyue Dong, Rui Lin, Xu Wang, Bin Bi, Yanlin |
author_facet | Tang, Xinhui Yv, Hui Wang, Fei Wang, Jiahan Liu, Siyv Wu, Xiaoyue Dong, Rui Lin, Xu Wang, Bin Bi, Yanlin |
author_sort | Tang, Xinhui |
collection | PubMed |
description | BACKGROUND: Although it has been proven that social networks are related to cognition, studies are conducted to characterize the correlation between social networks and postoperative delirium (POD). OBJECTIVE: We investigated whether suboptimal social networks are a risk factor for POD, and to verify whether different levels of intimacy in the same social relationship can affect the concentration of cerebrospinal fluid (CSF) biomarkers, such as amyloid-β (Aβ42), total tau (T-tau), and phosphorylated tau (P-tau), and the mediating role of CSF biomarkers between social network and POD in middle-aged and elderly Han people. METHODS: Our study recruited 743 participants from The Perioperative Neurocognitive Disorder and Biomarker Lifestyle (PNDABLE) study. Confusion Assessment Method (CAM) was used to evaluate the incidence of POD and its severity was measured using the Memorial Delirium Assessment Scale (MDAS). The social networks were measured using self-reported questionnaires about social ties. Mann–Whitney U test, Logistic Regression and Independent-samples test were used for Statistical Analysis. RESULTS: The incidence of POD was 20.7%. Mann–Whitney U test showed that the total score of the social network was associated with POD (P < 0.001). Independent-samples test showed that different levels of intimacy in the same social relationship were significantly associated with CSF POD biomarkers, and mediation analyses revealed that the association between suboptimal social networks and POD was partially mediated by T-tau (proportion: 20%), P-tau (proportion: 33%), Aβ42/T-tau (proportion: 14%), and Aβ42/P-tau (proportion: 15%). CONCLUSION: Having suboptimal social networks is a risk factor for POD in middle-aged and elderly Han people. CSF POD biomarkers can mediate the correlation between suboptimal social networks and POD, which is mainly mediated by tau protein. CLINICAL TRIAL REGISTRATION: www.chictr.org.cn, identifier ChiCTR2000033439. |
format | Online Article Text |
id | pubmed-9235411 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-92354112022-06-28 The Relationship Between Suboptimal Social Networks and Postoperative Delirium: The PNDABLE Study Tang, Xinhui Yv, Hui Wang, Fei Wang, Jiahan Liu, Siyv Wu, Xiaoyue Dong, Rui Lin, Xu Wang, Bin Bi, Yanlin Front Aging Neurosci Neuroscience BACKGROUND: Although it has been proven that social networks are related to cognition, studies are conducted to characterize the correlation between social networks and postoperative delirium (POD). OBJECTIVE: We investigated whether suboptimal social networks are a risk factor for POD, and to verify whether different levels of intimacy in the same social relationship can affect the concentration of cerebrospinal fluid (CSF) biomarkers, such as amyloid-β (Aβ42), total tau (T-tau), and phosphorylated tau (P-tau), and the mediating role of CSF biomarkers between social network and POD in middle-aged and elderly Han people. METHODS: Our study recruited 743 participants from The Perioperative Neurocognitive Disorder and Biomarker Lifestyle (PNDABLE) study. Confusion Assessment Method (CAM) was used to evaluate the incidence of POD and its severity was measured using the Memorial Delirium Assessment Scale (MDAS). The social networks were measured using self-reported questionnaires about social ties. Mann–Whitney U test, Logistic Regression and Independent-samples test were used for Statistical Analysis. RESULTS: The incidence of POD was 20.7%. Mann–Whitney U test showed that the total score of the social network was associated with POD (P < 0.001). Independent-samples test showed that different levels of intimacy in the same social relationship were significantly associated with CSF POD biomarkers, and mediation analyses revealed that the association between suboptimal social networks and POD was partially mediated by T-tau (proportion: 20%), P-tau (proportion: 33%), Aβ42/T-tau (proportion: 14%), and Aβ42/P-tau (proportion: 15%). CONCLUSION: Having suboptimal social networks is a risk factor for POD in middle-aged and elderly Han people. CSF POD biomarkers can mediate the correlation between suboptimal social networks and POD, which is mainly mediated by tau protein. CLINICAL TRIAL REGISTRATION: www.chictr.org.cn, identifier ChiCTR2000033439. Frontiers Media S.A. 2022-06-13 /pmc/articles/PMC9235411/ /pubmed/35769605 http://dx.doi.org/10.3389/fnagi.2022.851368 Text en Copyright © 2022 Tang, Yv, Wang, Wang, Liu, Wu, Dong, Lin, Wang and Bi. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Neuroscience Tang, Xinhui Yv, Hui Wang, Fei Wang, Jiahan Liu, Siyv Wu, Xiaoyue Dong, Rui Lin, Xu Wang, Bin Bi, Yanlin The Relationship Between Suboptimal Social Networks and Postoperative Delirium: The PNDABLE Study |
title | The Relationship Between Suboptimal Social Networks and Postoperative Delirium: The PNDABLE Study |
title_full | The Relationship Between Suboptimal Social Networks and Postoperative Delirium: The PNDABLE Study |
title_fullStr | The Relationship Between Suboptimal Social Networks and Postoperative Delirium: The PNDABLE Study |
title_full_unstemmed | The Relationship Between Suboptimal Social Networks and Postoperative Delirium: The PNDABLE Study |
title_short | The Relationship Between Suboptimal Social Networks and Postoperative Delirium: The PNDABLE Study |
title_sort | relationship between suboptimal social networks and postoperative delirium: the pndable study |
topic | Neuroscience |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9235411/ https://www.ncbi.nlm.nih.gov/pubmed/35769605 http://dx.doi.org/10.3389/fnagi.2022.851368 |
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