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Clinical characteristics, outcomes, and management of COVID-19 in kidney transplant recipients across Asia: an ASTREGO report

BACKGROUND: Asia is the global epicenter of the coronavirus disease 2019 (COVID-19) pandemic; however, COVID-19–related mortality in Asia remains lower than in other parts of the world. It is uncertain whether the mortality of COVID-19-infected kidney transplant recipients (KTXs) from Asia follows t...

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Autores principales: Kee, Terence, Jeong, Jong Cheol, Ur-Rashid, Harun, Begum, Nura Afza Salma, Arakama, Mel-Hatra, Danguilan, Romina, Od-Erdene, Lkhaahuu, Yahya, Rosnawati, Kim, Yaerim, Sran, Hersharan Kaur, Ma, Becky, Ma, Maggie, Rana, Devinder Singh, Ahn, Curie, Ahmad, Ghazali
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Korean Society for Transplantation 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9235460/
https://www.ncbi.nlm.nih.gov/pubmed/35769859
http://dx.doi.org/10.4285/kjt.21.0024
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author Kee, Terence
Jeong, Jong Cheol
Ur-Rashid, Harun
Begum, Nura Afza Salma
Arakama, Mel-Hatra
Danguilan, Romina
Od-Erdene, Lkhaahuu
Yahya, Rosnawati
Kim, Yaerim
Sran, Hersharan Kaur
Ma, Becky
Ma, Maggie
Rana, Devinder Singh
Ahn, Curie
Ahmad, Ghazali
author_facet Kee, Terence
Jeong, Jong Cheol
Ur-Rashid, Harun
Begum, Nura Afza Salma
Arakama, Mel-Hatra
Danguilan, Romina
Od-Erdene, Lkhaahuu
Yahya, Rosnawati
Kim, Yaerim
Sran, Hersharan Kaur
Ma, Becky
Ma, Maggie
Rana, Devinder Singh
Ahn, Curie
Ahmad, Ghazali
author_sort Kee, Terence
collection PubMed
description BACKGROUND: Asia is the global epicenter of the coronavirus disease 2019 (COVID-19) pandemic; however, COVID-19–related mortality in Asia remains lower than in other parts of the world. It is uncertain whether the mortality of COVID-19-infected kidney transplant recipients (KTXs) from Asia follows the lower mortality trends of the younger Asian population. METHODS: Specific transplant centers from countries in the Asian Society of Transplantation were invited to participate in a study to examine the epidemiology, clinical features, natural history, and outcomes of COVID-19 infections in KTXs. Data were analyzed and compared with those of large cohort studies from other countries. RESULTS: The study population was 87 KTXs from nine hospitals in seven Asian countries. Within the study population, 9% were aged 60 years and older, and 79% had at least one comorbidity. The majority of patients (69%) presented with mild-to-moderate COVID-19 severity. Disease progression was more frequently encountered among those with moderate or severe infection (23%) and non-survivors (55%). The mortality rate was 23% (n=20) and differed according to the level of care 12% (n=1/8), 15% (n=10/67), and 100% (n=9/9) of patients managed as outpatients, in the general ward, and in the intensive care unit, respectively. Disease severity at the time of presentation was an independent predictor of mortality. Compared with the mortality rates in other studies worldwide, mortality rates in the current study were comparable. CONCLUSIONS: Mortality in Asian KTXs who were infected with COVID-19 remains high and could be related to comorbidity burden and the constraints of the general healthcare system when the COVID-19 caseload is high.
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spelling pubmed-92354602022-06-28 Clinical characteristics, outcomes, and management of COVID-19 in kidney transplant recipients across Asia: an ASTREGO report Kee, Terence Jeong, Jong Cheol Ur-Rashid, Harun Begum, Nura Afza Salma Arakama, Mel-Hatra Danguilan, Romina Od-Erdene, Lkhaahuu Yahya, Rosnawati Kim, Yaerim Sran, Hersharan Kaur Ma, Becky Ma, Maggie Rana, Devinder Singh Ahn, Curie Ahmad, Ghazali Korean J Transplant Original Article BACKGROUND: Asia is the global epicenter of the coronavirus disease 2019 (COVID-19) pandemic; however, COVID-19–related mortality in Asia remains lower than in other parts of the world. It is uncertain whether the mortality of COVID-19-infected kidney transplant recipients (KTXs) from Asia follows the lower mortality trends of the younger Asian population. METHODS: Specific transplant centers from countries in the Asian Society of Transplantation were invited to participate in a study to examine the epidemiology, clinical features, natural history, and outcomes of COVID-19 infections in KTXs. Data were analyzed and compared with those of large cohort studies from other countries. RESULTS: The study population was 87 KTXs from nine hospitals in seven Asian countries. Within the study population, 9% were aged 60 years and older, and 79% had at least one comorbidity. The majority of patients (69%) presented with mild-to-moderate COVID-19 severity. Disease progression was more frequently encountered among those with moderate or severe infection (23%) and non-survivors (55%). The mortality rate was 23% (n=20) and differed according to the level of care 12% (n=1/8), 15% (n=10/67), and 100% (n=9/9) of patients managed as outpatients, in the general ward, and in the intensive care unit, respectively. Disease severity at the time of presentation was an independent predictor of mortality. Compared with the mortality rates in other studies worldwide, mortality rates in the current study were comparable. CONCLUSIONS: Mortality in Asian KTXs who were infected with COVID-19 remains high and could be related to comorbidity burden and the constraints of the general healthcare system when the COVID-19 caseload is high. The Korean Society for Transplantation 2021-12-31 2021-12-31 /pmc/articles/PMC9235460/ /pubmed/35769859 http://dx.doi.org/10.4285/kjt.21.0024 Text en Copyright © 2021 The Korean Society for Transplantation https://creativecommons.org/licenses/by-nc/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0 (https://creativecommons.org/licenses/by-nc/4.0/) ) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Article
Kee, Terence
Jeong, Jong Cheol
Ur-Rashid, Harun
Begum, Nura Afza Salma
Arakama, Mel-Hatra
Danguilan, Romina
Od-Erdene, Lkhaahuu
Yahya, Rosnawati
Kim, Yaerim
Sran, Hersharan Kaur
Ma, Becky
Ma, Maggie
Rana, Devinder Singh
Ahn, Curie
Ahmad, Ghazali
Clinical characteristics, outcomes, and management of COVID-19 in kidney transplant recipients across Asia: an ASTREGO report
title Clinical characteristics, outcomes, and management of COVID-19 in kidney transplant recipients across Asia: an ASTREGO report
title_full Clinical characteristics, outcomes, and management of COVID-19 in kidney transplant recipients across Asia: an ASTREGO report
title_fullStr Clinical characteristics, outcomes, and management of COVID-19 in kidney transplant recipients across Asia: an ASTREGO report
title_full_unstemmed Clinical characteristics, outcomes, and management of COVID-19 in kidney transplant recipients across Asia: an ASTREGO report
title_short Clinical characteristics, outcomes, and management of COVID-19 in kidney transplant recipients across Asia: an ASTREGO report
title_sort clinical characteristics, outcomes, and management of covid-19 in kidney transplant recipients across asia: an astrego report
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9235460/
https://www.ncbi.nlm.nih.gov/pubmed/35769859
http://dx.doi.org/10.4285/kjt.21.0024
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