Structural basis for endoperoxide-forming oxygenases

Endoperoxide natural products are widely distributed in nature and exhibit various biological activities. Due to their chemical features, endoperoxide and endoperoxide-derived secondary metabolites have attracted keen attention in the field of natural products and organic synthesis. In this review,...

Descripción completa

Detalles Bibliográficos
Autores principales: Mori, Takahiro, Abe, Ikuro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Beilstein-Institut 2022
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9235837/
https://www.ncbi.nlm.nih.gov/pubmed/35821691
http://dx.doi.org/10.3762/bjoc.18.71
_version_ 1784736404639580160
author Mori, Takahiro
Abe, Ikuro
author_facet Mori, Takahiro
Abe, Ikuro
author_sort Mori, Takahiro
collection PubMed
description Endoperoxide natural products are widely distributed in nature and exhibit various biological activities. Due to their chemical features, endoperoxide and endoperoxide-derived secondary metabolites have attracted keen attention in the field of natural products and organic synthesis. In this review, we summarize the structural analyses, mechanistic investigations, and proposed reaction mechanisms of endoperoxide-forming oxygenases, including cyclooxygenase, fumitremorgin B endoperoxidase (FtmOx1), and the asnovolin A endoperoxygenase NvfI.
format Online
Article
Text
id pubmed-9235837
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher Beilstein-Institut
record_format MEDLINE/PubMed
spelling pubmed-92358372022-07-11 Structural basis for endoperoxide-forming oxygenases Mori, Takahiro Abe, Ikuro Beilstein J Org Chem Review Endoperoxide natural products are widely distributed in nature and exhibit various biological activities. Due to their chemical features, endoperoxide and endoperoxide-derived secondary metabolites have attracted keen attention in the field of natural products and organic synthesis. In this review, we summarize the structural analyses, mechanistic investigations, and proposed reaction mechanisms of endoperoxide-forming oxygenases, including cyclooxygenase, fumitremorgin B endoperoxidase (FtmOx1), and the asnovolin A endoperoxygenase NvfI. Beilstein-Institut 2022-06-21 /pmc/articles/PMC9235837/ /pubmed/35821691 http://dx.doi.org/10.3762/bjoc.18.71 Text en Copyright © 2022, Mori and Abe https://creativecommons.org/licenses/by/4.0/This is an open access article licensed under the terms of the Beilstein-Institut Open Access License Agreement (https://www.beilstein-journals.org/bjoc/terms/terms), which is identical to the Creative Commons Attribution 4.0 International License (https://creativecommons.org/licenses/by/4.0 (https://creativecommons.org/licenses/by/4.0/) ). The reuse of material under this license requires that the author(s), source and license are credited. Third-party material in this article could be subject to other licenses (typically indicated in the credit line), and in this case, users are required to obtain permission from the license holder to reuse the material.
spellingShingle Review
Mori, Takahiro
Abe, Ikuro
Structural basis for endoperoxide-forming oxygenases
title Structural basis for endoperoxide-forming oxygenases
title_full Structural basis for endoperoxide-forming oxygenases
title_fullStr Structural basis for endoperoxide-forming oxygenases
title_full_unstemmed Structural basis for endoperoxide-forming oxygenases
title_short Structural basis for endoperoxide-forming oxygenases
title_sort structural basis for endoperoxide-forming oxygenases
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9235837/
https://www.ncbi.nlm.nih.gov/pubmed/35821691
http://dx.doi.org/10.3762/bjoc.18.71
work_keys_str_mv AT moritakahiro structuralbasisforendoperoxideformingoxygenases
AT abeikuro structuralbasisforendoperoxideformingoxygenases

Ejemplares similares