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A case of microsatellite instability-high clinically advanced castration-resistant prostate cancer showing a remarkable response to pembrolizumab sustained over at least 18 months

Defective DNA mismatch repair genes can lead to microsatellite instability (MSI)-high status in prostate cancer (PC). Accumulation of replication errors in DNA leads to the production of abundant neoantigens, which could be targets for immune checkpoint inhibitors (CPIs). However, the incidence of M...

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Detalles Bibliográficos
Autores principales:	Shimizu, Kosuke, Sano, Takeshi, Mizuno, Kei, Sunada, Takuro, Makita, Noriyuki, Hagimoto, Hiroki, Goto, Takayuki, Sawada, Atsuro, Fujimoto, Masakazu, Ichioka, Kentaro, Ogawa, Osamu, Kobayashi, Takashi, Akamatsu, Shusuke
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Cold Spring Harbor Laboratory Press 2022
Materias:	Research Report
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9235847/ https://www.ncbi.nlm.nih.gov/pubmed/35487690 http://dx.doi.org/10.1101/mcs.a006194

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