Targeting Trimethylamine N-Oxide: A New Therapeutic Strategy for Alleviating Atherosclerosis

Atherosclerosis (AS) is one of the most common cardiovascular diseases (CVDs), and there is currently no effective drug to reverse its pathogenesis. Trimethylamine N-oxide (TMAO) is a metabolite of the gut flora with the potential to act as a new risk factor for CVD. Many studies have shown that TMA...

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Autores principales: Jing, Lele, Zhang, Honghong, Xiang, Qiannan, Shen, Liang, Guo, Xiaoxia, Zhai, Changlin, Hu, Huilin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Cardiovascular Medicine
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9235870/
https://www.ncbi.nlm.nih.gov/pubmed/35770223
http://dx.doi.org/10.3389/fcvm.2022.864600
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author Jing, Lele
Zhang, Honghong
Xiang, Qiannan
Shen, Liang
Guo, Xiaoxia
Zhai, Changlin
Hu, Huilin
author_facet Jing, Lele
Zhang, Honghong
Xiang, Qiannan
Shen, Liang
Guo, Xiaoxia
Zhai, Changlin
Hu, Huilin
author_sort Jing, Lele
collection PubMed
description Atherosclerosis (AS) is one of the most common cardiovascular diseases (CVDs), and there is currently no effective drug to reverse its pathogenesis. Trimethylamine N-oxide (TMAO) is a metabolite of the gut flora with the potential to act as a new risk factor for CVD. Many studies have shown that TMAO is involved in the occurrence and development of atherosclerotic diseases through various mechanisms; however, the targeted therapy for TMAO remains controversial. This article summarizes the vital progress made in relation to evaluations on TMAO and AS in recent years and highlights novel probable approaches for the prevention and treatment of AS.
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spelling pubmed-92358702022-06-28 Targeting Trimethylamine N-Oxide: A New Therapeutic Strategy for Alleviating Atherosclerosis Jing, Lele Zhang, Honghong Xiang, Qiannan Shen, Liang Guo, Xiaoxia Zhai, Changlin Hu, Huilin Front Cardiovasc Med Cardiovascular Medicine Atherosclerosis (AS) is one of the most common cardiovascular diseases (CVDs), and there is currently no effective drug to reverse its pathogenesis. Trimethylamine N-oxide (TMAO) is a metabolite of the gut flora with the potential to act as a new risk factor for CVD. Many studies have shown that TMAO is involved in the occurrence and development of atherosclerotic diseases through various mechanisms; however, the targeted therapy for TMAO remains controversial. This article summarizes the vital progress made in relation to evaluations on TMAO and AS in recent years and highlights novel probable approaches for the prevention and treatment of AS. Frontiers Media S.A. 2022-06-13 /pmc/articles/PMC9235870/ /pubmed/35770223 http://dx.doi.org/10.3389/fcvm.2022.864600 Text en Copyright © 2022 Jing, Zhang, Xiang, Shen, Guo, Zhai and Hu. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Cardiovascular Medicine
Jing, Lele
Zhang, Honghong
Xiang, Qiannan
Shen, Liang
Guo, Xiaoxia
Zhai, Changlin
Hu, Huilin
Targeting Trimethylamine N-Oxide: A New Therapeutic Strategy for Alleviating Atherosclerosis
title Targeting Trimethylamine N-Oxide: A New Therapeutic Strategy for Alleviating Atherosclerosis
title_full Targeting Trimethylamine N-Oxide: A New Therapeutic Strategy for Alleviating Atherosclerosis
title_fullStr Targeting Trimethylamine N-Oxide: A New Therapeutic Strategy for Alleviating Atherosclerosis
title_full_unstemmed Targeting Trimethylamine N-Oxide: A New Therapeutic Strategy for Alleviating Atherosclerosis
title_short Targeting Trimethylamine N-Oxide: A New Therapeutic Strategy for Alleviating Atherosclerosis
title_sort targeting trimethylamine n-oxide: a new therapeutic strategy for alleviating atherosclerosis
topic Cardiovascular Medicine
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9235870/
https://www.ncbi.nlm.nih.gov/pubmed/35770223
http://dx.doi.org/10.3389/fcvm.2022.864600
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