Rapid gas–liquid reaction in flow. Continuous synthesis and production of cyclohexene oxide

The enhanced reaction rate in the epoxidation of cyclohexene with air as an oxidant was discovered without any added catalyst utilizing a continuous flow reactor constructed with readily available stainless steel parts and devices. This continuous-flow process demonstrates a significant improvement...

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Autores principales: Mandai, Kyoko, Yamamoto, Tetsuya, Mandai, Hiroki, Nagaki, Aiichiro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Beilstein-Institut 2022
Materias:
Letter
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9235905/
https://www.ncbi.nlm.nih.gov/pubmed/35821694
http://dx.doi.org/10.3762/bjoc.18.67
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author Mandai, Kyoko
Yamamoto, Tetsuya
Mandai, Hiroki
Nagaki, Aiichiro
author_facet Mandai, Kyoko
Yamamoto, Tetsuya
Mandai, Hiroki
Nagaki, Aiichiro
author_sort Mandai, Kyoko
collection PubMed
description The enhanced reaction rate in the epoxidation of cyclohexene with air as an oxidant was discovered without any added catalyst utilizing a continuous flow reactor constructed with readily available stainless steel parts and devices. This continuous-flow process demonstrates a significant improvement in reaction time for highly selective epoxide production over the batch process due to the efficient mass transfer between the liquid phase and air. The flow process discovered was operated continuously with good operational stability, evaluated by a constant high yield of cyclohexene oxide, to obtain the desired product with high productivity.
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spelling pubmed-92359052022-07-11 Rapid gas–liquid reaction in flow. Continuous synthesis and production of cyclohexene oxide Mandai, Kyoko Yamamoto, Tetsuya Mandai, Hiroki Nagaki, Aiichiro Beilstein J Org Chem Letter The enhanced reaction rate in the epoxidation of cyclohexene with air as an oxidant was discovered without any added catalyst utilizing a continuous flow reactor constructed with readily available stainless steel parts and devices. This continuous-flow process demonstrates a significant improvement in reaction time for highly selective epoxide production over the batch process due to the efficient mass transfer between the liquid phase and air. The flow process discovered was operated continuously with good operational stability, evaluated by a constant high yield of cyclohexene oxide, to obtain the desired product with high productivity. Beilstein-Institut 2022-06-13 /pmc/articles/PMC9235905/ /pubmed/35821694 http://dx.doi.org/10.3762/bjoc.18.67 Text en Copyright © 2022, Mandai et al. https://creativecommons.org/licenses/by/4.0/This is an open access article licensed under the terms of the Beilstein-Institut Open Access License Agreement (https://www.beilstein-journals.org/bjoc/terms/terms), which is identical to the Creative Commons Attribution 4.0 International License (https://creativecommons.org/licenses/by/4.0 (https://creativecommons.org/licenses/by/4.0/) ). The reuse of material under this license requires that the author(s), source and license are credited. Third-party material in this article could be subject to other licenses (typically indicated in the credit line), and in this case, users are required to obtain permission from the license holder to reuse the material.
spellingShingle Letter
Mandai, Kyoko
Yamamoto, Tetsuya
Mandai, Hiroki
Nagaki, Aiichiro
Rapid gas–liquid reaction in flow. Continuous synthesis and production of cyclohexene oxide
title Rapid gas–liquid reaction in flow. Continuous synthesis and production of cyclohexene oxide
title_full Rapid gas–liquid reaction in flow. Continuous synthesis and production of cyclohexene oxide
title_fullStr Rapid gas–liquid reaction in flow. Continuous synthesis and production of cyclohexene oxide
title_full_unstemmed Rapid gas–liquid reaction in flow. Continuous synthesis and production of cyclohexene oxide
title_short Rapid gas–liquid reaction in flow. Continuous synthesis and production of cyclohexene oxide
title_sort rapid gas–liquid reaction in flow. continuous synthesis and production of cyclohexene oxide
topic Letter
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9235905/
https://www.ncbi.nlm.nih.gov/pubmed/35821694
http://dx.doi.org/10.3762/bjoc.18.67
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