The cGAS-STING Pathway Affects Vertebral Bone but Does Not Promote Intervertebral Disc Cell Senescence or Degeneration

The DNA-sensing cGAS-STING pathway promotes the senescence-associated secretory phenotype (SASP) and mediates type-I interferon inflammatory responses to foreign viral and bacterial DNA as well as self-DNA. Studies of the intervertebral disc in humans and mice demonstrate associations between aging,...

Descripción completa

Detalles Bibliográficos
Autores principales: Ottone, Olivia K., Kim, C. James, Collins, John A., Risbud, Makarand V.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9235924/
https://www.ncbi.nlm.nih.gov/pubmed/35769461
http://dx.doi.org/10.3389/fimmu.2022.882407

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9235924/
https://www.ncbi.nlm.nih.gov/pubmed/35769461
http://dx.doi.org/10.3389/fimmu.2022.882407

Ejemplares similares