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The cGAS-STING Pathway Affects Vertebral Bone but Does Not Promote Intervertebral Disc Cell Senescence or Degeneration

The DNA-sensing cGAS-STING pathway promotes the senescence-associated secretory phenotype (SASP) and mediates type-I interferon inflammatory responses to foreign viral and bacterial DNA as well as self-DNA. Studies of the intervertebral disc in humans and mice demonstrate associations between aging,...

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Detalles Bibliográficos
Autores principales:	Ottone, Olivia K., Kim, C. James, Collins, John A., Risbud, Makarand V.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2022
Materias:	Immunology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9235924/ https://www.ncbi.nlm.nih.gov/pubmed/35769461 http://dx.doi.org/10.3389/fimmu.2022.882407

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