Roles of Autotaxin/Autotaxin-Lysophosphatidic Acid Axis in the Initiation and Progression of Liver Cancer

Autotaxin (ATX) is a secreted glycoprotein and catalyzes the hydrolysis of lysophosphatidylcholine to lysophosphatidic acid (LPA), a growth factor-like signaling phospholipid. ATX has been abundantly detected in the culture medium of various cancer cells, tumor tissues, and serum or plasma of cancer...

Descripción completa

Detalles Bibliográficos
Autores principales: She, Sha, Zhang, Qian, Shi, Jinzhi, Yang, Fan, Dai, Kai
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Oncology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9236130/
https://www.ncbi.nlm.nih.gov/pubmed/35769713
http://dx.doi.org/10.3389/fonc.2022.922945
_version_ 1784736465397219328
author She, Sha
Zhang, Qian
Shi, Jinzhi
Yang, Fan
Dai, Kai
author_facet She, Sha
Zhang, Qian
Shi, Jinzhi
Yang, Fan
Dai, Kai
author_sort She, Sha
collection PubMed
description Autotaxin (ATX) is a secreted glycoprotein and catalyzes the hydrolysis of lysophosphatidylcholine to lysophosphatidic acid (LPA), a growth factor-like signaling phospholipid. ATX has been abundantly detected in the culture medium of various cancer cells, tumor tissues, and serum or plasma of cancer patients. Biological actions of ATX are mediated by LPA. The ATX-LPA axis mediates a plethora of activities, such as cell proliferation, survival, migration, angiogenesis, and inflammation, and participates in the regulation of various physiological and pathological processes. In this review, we have summarized the physiological function of ATX and the ATX-LPA axis in liver cancer, analyzed the role of the ATX-LPA axis in tumorigenesis and metastasis, and discussed the therapeutic strategies targeting the ATX-LPA axis, paving the way for new therapeutic developments.
format Online
Article
Text
id pubmed-9236130
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher Frontiers Media S.A.
record_format MEDLINE/PubMed
spelling pubmed-92361302022-06-28 Roles of Autotaxin/Autotaxin-Lysophosphatidic Acid Axis in the Initiation and Progression of Liver Cancer She, Sha Zhang, Qian Shi, Jinzhi Yang, Fan Dai, Kai Front Oncol Oncology Autotaxin (ATX) is a secreted glycoprotein and catalyzes the hydrolysis of lysophosphatidylcholine to lysophosphatidic acid (LPA), a growth factor-like signaling phospholipid. ATX has been abundantly detected in the culture medium of various cancer cells, tumor tissues, and serum or plasma of cancer patients. Biological actions of ATX are mediated by LPA. The ATX-LPA axis mediates a plethora of activities, such as cell proliferation, survival, migration, angiogenesis, and inflammation, and participates in the regulation of various physiological and pathological processes. In this review, we have summarized the physiological function of ATX and the ATX-LPA axis in liver cancer, analyzed the role of the ATX-LPA axis in tumorigenesis and metastasis, and discussed the therapeutic strategies targeting the ATX-LPA axis, paving the way for new therapeutic developments. Frontiers Media S.A. 2022-06-13 /pmc/articles/PMC9236130/ /pubmed/35769713 http://dx.doi.org/10.3389/fonc.2022.922945 Text en Copyright © 2022 She, Zhang, Shi, Yang and Dai https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Oncology
She, Sha
Zhang, Qian
Shi, Jinzhi
Yang, Fan
Dai, Kai
Roles of Autotaxin/Autotaxin-Lysophosphatidic Acid Axis in the Initiation and Progression of Liver Cancer
title Roles of Autotaxin/Autotaxin-Lysophosphatidic Acid Axis in the Initiation and Progression of Liver Cancer
title_full Roles of Autotaxin/Autotaxin-Lysophosphatidic Acid Axis in the Initiation and Progression of Liver Cancer
title_fullStr Roles of Autotaxin/Autotaxin-Lysophosphatidic Acid Axis in the Initiation and Progression of Liver Cancer
title_full_unstemmed Roles of Autotaxin/Autotaxin-Lysophosphatidic Acid Axis in the Initiation and Progression of Liver Cancer
title_short Roles of Autotaxin/Autotaxin-Lysophosphatidic Acid Axis in the Initiation and Progression of Liver Cancer
title_sort roles of autotaxin/autotaxin-lysophosphatidic acid axis in the initiation and progression of liver cancer
topic Oncology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9236130/
https://www.ncbi.nlm.nih.gov/pubmed/35769713
http://dx.doi.org/10.3389/fonc.2022.922945
work_keys_str_mv AT shesha rolesofautotaxinautotaxinlysophosphatidicacidaxisintheinitiationandprogressionoflivercancer
AT zhangqian rolesofautotaxinautotaxinlysophosphatidicacidaxisintheinitiationandprogressionoflivercancer
AT shijinzhi rolesofautotaxinautotaxinlysophosphatidicacidaxisintheinitiationandprogressionoflivercancer
AT yangfan rolesofautotaxinautotaxinlysophosphatidicacidaxisintheinitiationandprogressionoflivercancer
AT daikai rolesofautotaxinautotaxinlysophosphatidicacidaxisintheinitiationandprogressionoflivercancer

Ejemplares similares