Host Kinase CSNK2 is a Target for Inhibition of Pathogenic SARS-like β-Coronaviruses

[Image: see text] Inhibition of the protein kinase CSNK2 with any of 30 specific and selective inhibitors representing different chemotypes, blocked replication of pathogenic human, bat, and murine β-coronaviruses. The potency of in-cell CSNK2A target engagement across the set of inhibitors correlat...

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Detalles Bibliográficos
Autores principales: Yang, Xuan, Dickmander, Rebekah J., Bayati, Armin, Taft-Benz, Sharon A., Smith, Jeffery L., Wells, Carrow I., Madden, Emily A., Brown, Jason W., Lenarcic, Erik M., Yount, Boyd L., Chang, Edcon, Axtman, Alison D., Baric, Ralph S., Heise, Mark T., McPherson, Peter S., Moorman, Nathaniel J., Willson, Timothy M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2022
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9236220/
https://www.ncbi.nlm.nih.gov/pubmed/35723434
http://dx.doi.org/10.1021/acschembio.2c00378

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